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    BACE1 beta-secretase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 614333, updated on 29-Jan-2025

    Summary

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    Official Symbol
    BACE1provided by VGNC
    Official Full Name
    beta-secretase 1provided by VGNC
    Primary source
    VGNC:VGNC:26400
    See related
    BGD:BT25553; Ensembl:ENSBTAG00000019365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BACE1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (27972060..27993773, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene ring finger protein 214 Neighboring gene centrosomal protein 164 Neighboring gene DS cell adhesion molecule like 1 Neighboring gene uncharacterized LOC132342316

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137940

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-secretase 1
    Names
    beta-site APP-cleaving enzyme 1
    beta-site amyloid precursor protein cleaving enzyme 1
    memapsin-2
    membrane-associated aspartic protease 2
    NP_001039996.1
    XP_005215919.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046531.1 → NP_001039996.1  beta-secretase 1 precursor

      See identical proteins and their annotated locations for NP_001039996.1

      Status: PROVISIONAL

      Source sequence(s)
      BC113325
      UniProtKB/Swiss-Prot
      Q2HJ40
      UniProtKB/TrEMBL
      A0AAF6ZE40
      Related
      ENSBTAP00070042229.1, ENSBTAT00070069280.1
      Conserved Domains (2) summary
      cd05473
      Location:72 → 437
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:75 → 416
      Asp; Eukaryotic aspartyl protease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27972060..27993773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005215862.5 → XP_005215919.1  beta-secretase 1 isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZE40
      Conserved Domains (2) summary
      cd05473
      Location:72 → 434
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
      pfam00026
      Location:75 → 416
      Asp; Eukaryotic aspartyl protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HJ40.1 GenPept UniProtKB/Swiss-Prot:Q2HJ40

    Gene LinkOut

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