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    STAT6 signal transducer and activator of transcription 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 353105, updated on 27-Dec-2024

    Summary

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    Official Symbol
    STAT6provided by VGNC
    Official Full Name
    signal transducer and activator of transcription 6provided by VGNC
    Primary source
    VGNC:VGNC:35374
    See related
    BGD:BT12329; Ensembl:ENSBTAG00000006335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See STAT6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56326256..56340447)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345298 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene microRNA mir-2431 Neighboring gene NGFI-A binding protein 2 Neighboring gene glycine cleavage system protein H pseudogene Neighboring gene nuclear envelope integral membrane protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms in the STAT6 gene and their association with carcass traits in feedlot cattle. Rincon G, et al. Anim Genet, 2009 Dec. PMID 19519791
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
      Title: Polymorphisms in the STAT6 gene and their association with carcass traits in feedlot cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 6
    Names
    signal transducer and activator of transcription 6, interleukin-4 induced

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205501.1 → NP_001192430.1  signal transducer and activator of transcription 6

      See identical proteins and their annotated locations for NP_001192430.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      F1MGJ4
      Conserved Domains (5) summary
      cd10377
      Location:517 → 646
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      smart00964
      Location:2 → 115
      STAT_int; STAT protein, protein interaction domain
      pfam14596
      Location:655 → 847
      STAT6_C; STAT6 C-terminal
      pfam01017
      Location:178 → 271
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:273 → 526
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56326256..56340447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991408.2 → XP_024847176.1  signal transducer and activator of transcription 6 isoform X1

      UniProtKB/TrEMBL
      F1MGJ4
      Conserved Domains (5) summary
      cd10377
      Location:517 → 646
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      smart00964
      Location:2 → 115
      STAT_int; STAT protein, protein interaction domain
      pfam14596
      Location:655 → 847
      STAT6_C; STAT6 C-terminal
      pfam01017
      Location:178 → 271
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:273 → 526
      STAT_bind; STAT protein, DNA binding domain

    2. XM_005206514.5 → XP_005206571.1  signal transducer and activator of transcription 6 isoform X1

      See identical proteins and their annotated locations for XP_005206571.1

      UniProtKB/TrEMBL
      F1MGJ4
      Related
      ENSBTAP00000008311.5, ENSBTAT00000008311.7
      Conserved Domains (5) summary
      cd10377
      Location:517 → 646
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      smart00964
      Location:2 → 115
      STAT_int; STAT protein, protein interaction domain
      pfam14596
      Location:655 → 847
      STAT6_C; STAT6 C-terminal
      pfam01017
      Location:178 → 271
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:273 → 526
      STAT_bind; STAT protein, DNA binding domain

    3. XM_059886138.1 → XP_059742121.1  signal transducer and activator of transcription 6 isoform X2

    4. XM_024991412.2 → XP_024847180.1  signal transducer and activator of transcription 6 isoform X3

      Conserved Domains (5) summary
      cd10377
      Location:466 → 595
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      pfam14596
      Location:604 → 796
      STAT6_C; STAT6 C-terminal
      pfam01017
      Location:127 → 220
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:222 → 475
      STAT_bind; STAT protein, DNA binding domain
      cl03749
      Location:2 → 64
      STAT_int; STAT protein, protein interaction domain
    Nucleotide Protein Strain
    Heading Accession and Version

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