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    NR2F2 nuclear receptor subfamily 2 group F member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281945, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NR2F2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 2 group F member 2provided by VGNC
    Primary source
    VGNC:VGNC:32241
    See related
    BGD:BT10543; Ensembl:ENSBTAG00000018007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TFCOUP2
    Orthologs
    human mouse all
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    Genomic context

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    See NR2F2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (10562376..10575224, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L Neighboring gene uncharacterized LOC101907944 Neighboring gene uncharacterized LOC107131341 Neighboring gene uncharacterized LOC100847841

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The COUP transcription factor (COUP-TF) is directly involved in the regulation of oxytocin gene expression in luteinizing bovine granulosa cells. Wehrenberg U, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1449499
    2. Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells. Murayama C, et al. Mol Cell Biochem, 2008 Jul. PMID 18409030
    3. Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and hepatocyte nuclear factor 4gamma (HNF-4gamma) and HNF-4alpha regulate the bovine growth hormone receptor 1A promoter through a common DNA element. Xu Q, et al. J Mol Endocrinol, 2004 Jun. PMID 15171724
    4. Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21. Antoniou E, et al. Cytogenet Cell Genet, 1999. PMID 10343125
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
      Title: Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
    2. Results show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor 1A promoter activity by binding to a common DNA element
      Title: Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and hepatocyte nuclear factor 4gamma (HNF-4gamma) and HNF-4alpha regulate the bovine growth hormone receptor 1A promoter through a common DNA element.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC157288

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables retinoic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COUP transcription factor 2
    Names
    COUP transcription factor II
    COUP-TF II
    COUP-TF2
    apolipoprotein A1 regulatory protein 1
    nuclear receptor subfamily 2, group F, member 1
    transcription factor COUP 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174402.3 → NP_776827.1  COUP transcription factor 2

      See identical proteins and their annotated locations for NP_776827.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123677
      UniProtKB/Swiss-Prot
      Q08DL8, Q9TTR7
      UniProtKB/TrEMBL
      A0A3Q1LM85
      Related
      ENSBTAP00000023969.5, ENSBTAT00000023969.6
      Conserved Domains (2) summary
      cd06948
      Location:177 → 411
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:79 → 151
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10562376..10575224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221710.5 → XP_005221767.1  COUP transcription factor 2 isoform X2

      See identical proteins and their annotated locations for XP_005221767.1

      UniProtKB/TrEMBL
      A0AAF6DMB4, A4IFS2, F1MRV3
      Related
      ENSBTAP00000050863.3, ENSBTAT00000056488.4
      Conserved Domains (1) summary
      cd06948
      Location:44 → 278
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

    2. XM_024981611.2 → XP_024837379.1  COUP transcription factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q08DL8, Q9TTR7
      UniProtKB/TrEMBL
      A0A3Q1LM85
      Conserved Domains (2) summary
      cd06948
      Location:177 → 411
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:79 → 151
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTR7.1 GenPept UniProtKB/Swiss-Prot:Q9TTR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials