BIRC6 baculoviral IAP repeat containing 6 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: BIRC6provided by VGNC
Official Full Name: baculoviral IAP repeat containing 6provided by VGNC
Primary source: VGNC:VGNC:26502
See related: Ensembl:ENSBTAG00000027932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 75

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (14961141..15174772)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.
Title: Depletion of BIRC6 leads to retarded bovine early embryonic development and blastocyst formation in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_3561-3562:966881418:1 (e-PCR)
- UniSTS:269276

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cytokinesis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

Names: apollon

NP_001193511.1

EC 2.3.2.27

XP_024854609.1

EC 2.3.2.27

XP_024854610.1

EC 2.3.2.27

XP_024854611.1

EC 2.3.2.27

XP_024854612.1

EC 2.3.2.27

XP_024854613.1

EC 2.3.2.27

XP_024854614.1

EC 2.3.2.27

XP_024854615.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206582.1 → NP_001193511.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

Status: VALIDATED

Source sequence(s)

BM031877, DAAA02030445, DAAA02030446, DAAA02030447, DN520473, DV871423, DV909724, DV915148, DV925478, DY106959

UniProtKB/TrEMBL

A0A3Q1N8N0

Related

ENSBTAP00000067423.2, ENSBTAT00000084702.2

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4601 → 4739

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3469 → 3621

DUF3643; Protein of unknown function (DUF3643)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

Range

14961141..15174772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024998841.2 → XP_024854609.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X1

UniProtKB/TrEMBL

A0A3Q1N8N0, E1BE13

Related

ENSBTAP00000053672.4, ENSBTAT00000061440.4

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4628 → 4766

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3496 → 3648

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998843.2 → XP_024854611.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X3

UniProtKB/TrEMBL

A0A3Q1N8N0

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4619 → 4757

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3487 → 3639

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998842.2 → XP_024854610.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X2

UniProtKB/TrEMBL

A0A3Q1N8N0

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4622 → 4760

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3490 → 3642

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998846.2 → XP_024854614.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X6

UniProtKB/TrEMBL

A0A3Q1N8N0

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4595 → 4733

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3463 → 3615

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998844.2 → XP_024854612.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X4

UniProtKB/TrEMBL

A0A3Q1N8N0

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4614 → 4752

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3482 → 3634

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998845.2 → XP_024854613.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X5

UniProtKB/TrEMBL

A0A3Q1N8N0

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4605 → 4743

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3473 → 3625

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_024998847.2 → XP_024854615.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X7

UniProtKB/TrEMBL

A0A3Q1LQP1, A0A3Q1N8N0

Related

ENSBTAP00000059406.2, ENSBTAT00000070377.2

Conserved Domains (3) summary

cd00022
Location:287 → 360

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4584 → 4722

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3452 → 3604

BIRC6; Baculoviral IAP repeat-containing protein 6