SIRT2 sirtuin 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SIRT2provided by VGNC
Official Full Name: sirtuin 2provided by VGNC
Primary source: VGNC:VGNC:34631
See related: BGD:BT25510; Ensembl:ENSBTAG00000001776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (48594222..48614059, complement)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yin Yang 1 Is Essential for Transcriptional Activation of the Bovine Sirt2 Gene in Preadipocytes
Title: Yin Yang 1 Is Essential for Transcriptional Activation of the Bovine Sirt2 Gene in Preadipocytes.
These results provide insights into the potential mechanisms by which SIRT2-dependent deacetylation activity exerts its effects on oocyte quality.
Title: SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
the data support the hypothesis that SIRT2 regulates steroid hormone synthesis via the Peroxisome Proliferator-Activated Receptors/Liver X Receptor-alpha pathways in ovarian granulosa cells.
Title: SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRα pathways in bovine ovarian granular cells.
the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.
Title: Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
Title: Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus).
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT-) diplotypes performed better than other combinations.
Title: Expression of the SIRT2 gene and its relationship with body size traits in Qinchuan cattle (Bos taurus).
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
Title: Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle.

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General gene information

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Markers

MARC_8053-8054:996688245:1 (e-PCR)
- UniSTS:269879

SIRT2 (e-PCR)
- UniSTS:519294

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription factor binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-2

Names: NAD-dependent deacetylase sirtuin-2; sirtuin-like protein 2

NP_001107003.1

EC 3.5.1.-

XP_059732522.1

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113531.1 → NP_001107003.1 NAD-dependent protein deacetylase sirtuin-2

Status: VALIDATED

Source sequence(s)

CO876041, DN532360, DN546771, EE225228

UniProtKB/TrEMBL

B2CZT3

Related

ENSBTAP00000002327.7, ENSBTAT00000002327.7

Conserved Domains (1) summary

cd01408
Location:77 → 331

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...