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    DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 [ Bos taurus (domestic cattle) ]

    Gene ID: 282216, updated on 27-Dec-2024

    Summary

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    Gene symbol
    DNAJC5
    Gene description
    DnaJ heat shock protein family (Hsp40) member C5
    See related
    BGD:BT26630; Ensembl:ENSBTAG00000015796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DNAJC5 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (53907615..53936626, complement)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346926 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene microRNA mir-1388 Neighboring gene TPD52 like 2 Neighboring gene abhydrolase domain containing 16B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel cysteine string protein variant and expression of cysteine string proteins in non-neuronal cells. Chamberlain LH, et al. J Biol Chem, 1996 Mar 29. PMID 8631751
    2. Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. Lemonidis K, et al. J Biol Chem, 2015 Sep 4. PMID 26198635, Free PMC Article
    3. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J, et al. J Biol Chem, 2008 Sep 5. PMID 18596047, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 5
    Names
    CSP
    DnaJ (Hsp40) homolog, subfamily C, member 5
    cysteine string protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174533.4 → NP_776958.2  dnaJ homolog subfamily C member 5

      See identical proteins and their annotated locations for NP_776958.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      BC120234, EE238321, NKLS02000013
      UniProtKB/Swiss-Prot
      Q0VCC7, Q29455, Q29456
      Related
      ENSBTAP00000059567.1, ENSBTAT00000070817.2
      Conserved Domains (1) summary
      COG0484
      Location:15 → 84
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_120605.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' region and includes an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      NKLS02000013

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      53907615..53936626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010811366.4 → XP_010809668.1  dnaJ homolog subfamily C member 5 isoform X1

      See identical proteins and their annotated locations for XP_010809668.1

      UniProtKB/Swiss-Prot
      Q0VCC7, Q29455, Q29456
      Conserved Domains (1) summary
      COG0484
      Location:15 → 84
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_236996.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29455.1 GenPept UniProtKB/Swiss-Prot:Q29455

    Gene LinkOut

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