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    RASGRP1 RAS guanyl releasing protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 533125, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RASGRP1provided by VGNC
    Official Full Name
    RAS guanyl releasing protein 1provided by VGNC
    Primary source
    VGNC:VGNC:33747
    See related
    BGD:BT16095; Ensembl:ENSBTAG00000021872
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RASGRP1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (34098460..34179229, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107132843 Neighboring gene family with sequence similarity 98 member B Neighboring gene uncharacterized LOC112448559 Neighboring gene thrombospondin 1 Neighboring gene fibrous sheath interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Segregation of the hereditary thrombopathia-associated polymorphism in polled German Fleckvieh cattle. Zerbin I, et al. Anim Genet, 2015 Oct. PMID 26154292
    2. Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells. Rchiad Z, et al. Cell Microbiol, 2020 Dec. PMID 32830401, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.
      Title: Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.
    2. a mutation in RASGRP1 is associated with hereditary thrombopathia in polled German Fleckvieh cattle
      Title: Segregation of the hereditary thrombopathia-associated polymorphism in polled German Fleckvieh cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAS guanyl-releasing protein 1
    Names
    RAS guanyl releasing protein 1 (calcium and DAG-regulated)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144078.1 → NP_001137550.1  RAS guanyl-releasing protein 1

      See identical proteins and their annotated locations for NP_001137550.1

      Status: INFERRED

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      A0AAA9T1S5, E1BG59
      Related
      ENSBTAP00000029159.6, ENSBTAT00000029159.7
      Conserved Domains (4) summary
      smart00147
      Location:201 → 437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54 → 175
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:542 → 591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478 → 527
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34098460..34179229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211584.4 → XP_005211641.1  RAS guanyl-releasing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SKP8, A0AAA9T1S5
      Related
      ENSBTAP00000085863.1, ENSBTAT00000133518.1
      Conserved Domains (4) summary
      smart00147
      Location:201 → 437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54 → 175
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:507 → 556
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:443 → 492
      EF-hand_7; EF-hand domain pair

    2. XM_015473118.3 → XP_015328604.1  RAS guanyl-releasing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T1S5
      Conserved Domains (4) summary
      smart00147
      Location:153 → 389
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:6 → 127
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:494 → 543
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:430 → 479
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version

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