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    NR3C1 nuclear receptor subfamily 3 group C member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281946, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NR3C1provided by VGNC
    Official Full Name
    nuclear receptor subfamily 3 group C member 1provided by VGNC
    Primary source
    VGNC:VGNC:32243
    See related
    BGD:BT11806; Ensembl:ENSBTAG00000019472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GR-A
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See NR3C1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (54344785..54491820, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847454 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene fibroblast growth factor 1 Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC132345824 Neighboring gene uncharacterized LOC107132646 Neighboring gene heterogeneous nuclear ribonucleoproteins A2/B1-like Neighboring gene Yip1 domain family member 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary. Rodríguez FM, et al. Theriogenology, 2023 Nov. PMID 37677868
    2. Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary. Amweg AN, et al. Cells Tissues Organs, 2016. PMID 26677854
    3. Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter. El-Mayet FS, et al. J Virol, 2024 Jan 23. PMID 38084958, Free PMC Article
    4. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement. Nayebosadri A, et al. Ann Biomed Eng, 2012 Jul. PMID 22227972
    5. Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells. James ER, et al. Invest Ophthalmol Vis Sci, 2003 Dec. PMID 14638726

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter.
      Title: Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter.
    2. Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary.
      Title: Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary.
    3. Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
      Title: Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary.
    4. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
      Title: Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.
    5. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
      Title: Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement.
    6. investigation of gene expression for GR, 11HSD1, and 11HSD2 in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
      Title: Gene expression of 11β-HSD and glucocorticoid receptor in the bovine (Bos taurus) follicle during follicular maturation and atresia: the role of follicular stimulating hormone.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucocorticoid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucocorticoid receptor
    Names
    glucocorticoid receptor alpha
    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206634.1 → NP_001193563.1  glucocorticoid receptor

      See identical proteins and their annotated locations for NP_001193563.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000007
      UniProtKB/TrEMBL
      F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:535 → 781
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 498
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54344785..54491820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993837.2 → XP_024849605.1  glucocorticoid receptor isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:536 → 782
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 499
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    2. XM_059887929.1 → XP_059743912.1  glucocorticoid receptor isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19

    3. XM_024993840.2 → XP_024849608.1  glucocorticoid receptor isoform X2

      UniProtKB/TrEMBL
      F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:535 → 781
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 498
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    4. XM_005209530.5 → XP_005209587.1  glucocorticoid receptor isoform X1

      See identical proteins and their annotated locations for XP_005209587.1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:536 → 782
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 499
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    5. XM_024993839.2 → XP_024849607.1  glucocorticoid receptor isoform X2

      UniProtKB/TrEMBL
      F1MN19
      Related
      ENSBTAP00000025941.5, ENSBTAT00000025941.6
      Conserved Domains (3) summary
      cd07076
      Location:535 → 781
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 498
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    6. XM_005209529.5 → XP_005209586.1  glucocorticoid receptor isoform X1

      See identical proteins and their annotated locations for XP_005209586.1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:536 → 782
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 499
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    7. XM_059887931.1 → XP_059743914.1  glucocorticoid receptor isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19

    8. XM_005209528.5 → XP_005209585.1  glucocorticoid receptor isoform X1

      See identical proteins and their annotated locations for XP_005209585.1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19
      Related
      ENSBTAP00000069782.2, ENSBTAT00000077017.2
      Conserved Domains (3) summary
      cd07076
      Location:536 → 782
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 499
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    9. XM_005209531.4 → XP_005209588.1  glucocorticoid receptor isoform X1

      See identical proteins and their annotated locations for XP_005209588.1

      UniProtKB/TrEMBL
      A0A3Q1M7I4, F1MN19
      Conserved Domains (3) summary
      cd07076
      Location:536 → 782
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:421 → 499
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:27 → 406
      GCR; Glucocorticoid receptor

    10. XM_059887932.1 → XP_059743915.1  glucocorticoid receptor isoform X3

      UniProtKB/TrEMBL
      F1MN19

    RNA

    1. XR_009495049.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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