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    DLD dihydrolipoamide dehydrogenase [ Bos taurus (domestic cattle) ]

    Gene ID: 533910, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DLDprovided by VGNC
    Official Full Name
    dihydrolipoamide dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:28085
    See related
    BGD:BT21920; Ensembl:ENSBTAG00000001908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DLD in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (48953232..48979994)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 3 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC132345088 Neighboring gene laminin subunit beta 1 Neighboring gene microRNA mir-2418

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production. Kareyeva AV, et al. FEBS Lett, 2011 Jan 21. PMID 21168410, Free PMC Article
    2. Lipoamide dehydrogenase and diaphorase catalyzed conversion of some NO donors to NO and reduction of NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO). Stibingerová A, et al. Gen Physiol Biophys, 2009 Dec. PMID 20097961
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. purification and identification of Bos taurus dihydrolipoyl dehydrogenase from heart mitochondria
      Title: Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production.
    2. Lipoamide dehydrogenase significantly accelerates the conversion of a defined subset of NO donors to NO.
      Title: Lipoamide dehydrogenase and diaphorase catalyzed conversion of some NO donors to NO and reduction of NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dihydrolipoyl dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrolipoyl dehydrogenase, mitochondrial
    NP_001193099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206170.3 → NP_001193099.1  dihydrolipoyl dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001193099.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000004
      UniProtKB/Swiss-Prot
      F1N206
      UniProtKB/TrEMBL
      A0AAA9TR97
      Related
      ENSBTAP00000033696.4, ENSBTAT00000033787.6
      Conserved Domains (1) summary
      cl27343
      Location:40 → 501
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48953232..48979994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1N206.2 GenPept UniProtKB/Swiss-Prot:F1N206

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.