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    Rab11fip4 RAB11 family interacting protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303337, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rab11fip4provided by RGD
    Official Full Name
    RAB11 family interacting protein 4provided by RGD
    Primary source
    RGD:1305063
    See related
    EnsemblRapid:ENSRNOG00000014135 AllianceGenome:RGD:1305063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305063
    Summary
    Predicted to enable protein homodimerization activity and small GTPase binding activity. Predicted to be involved in endocytic recycling and regulation of cytokinesis. Predicted to be located in endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 213.6), Kidney (RPKM 78.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab11fip4 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65048070..65156086)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64550109..64658123)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66942363..67051672)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene neurofibromin 1 Neighboring gene ecotropic viral integration site 2B Neighboring gene U6 spliceosomal RNA Neighboring gene ecotropic viral integration site 2A Neighboring gene uncharacterized LOC134480704 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102550168 Neighboring gene transfer RNA threonine (anticodon CGU) 1 Neighboring gene microRNA 193a Neighboring gene microRNA 193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner. Muto A, et al. Dev Dyn, 2007 Jan. PMID 17089410
    2. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Wallace DM, et al. Biochem Biophys Res Commun, 2002 Dec 20. PMID 12470645
    3. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Wilson GM, et al. Mol Biol Cell, 2005 Feb. PMID 15601896, Free PMC Article
    4. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. Fielding AB, et al. EMBO J, 2005 Oct 5. PMID 16148947, Free PMC Article
    5. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al. J Biol Chem, 2010 Oct 8. PMID 20682791, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural retina development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G1 to G0 transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 4
    Names
    RAB11 family interacting protein 4 (class II)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107023.1 → NP_001100493.1  rab11 family-interacting protein 4

      See identical proteins and their annotated locations for NP_001100493.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HH90, D3ZHE5
      Related
      ENSRNOP00000018988.3, ENSRNOT00000018986.6
      Conserved Domains (3) summary
      pfam09457
      Location:596 → 636
      RBD-FIP; FIP domain
      pfam13499
      Location:21 → 78
      EF-hand_7; EF-hand domain pair
      cl03075
      Location:428 → 512
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65048070..65156086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246903.5 → XP_006246965.1  rab11 family-interacting protein 4 isoform X1

      Conserved Domains (3) summary
      pfam09457
      Location:573 → 613
      RBD-FIP; FIP domain
      pfam13499
      Location:21 → 78
      EF-hand_7; EF-hand domain pair
      cl03075
      Location:405 → 489
      GrpE; nucleotide exchange factor GrpE

    2. XM_008768017.3 → XP_008766239.1  rab11 family-interacting protein 4 isoform X2

      Conserved Domains (2) summary
      pfam09457
      Location:516 → 556
      RBD-FIP; FIP domain
      cl03075
      Location:348 → 432
      GrpE; nucleotide exchange factor GrpE

    3. XM_006246904.5 → XP_006246966.1  rab11 family-interacting protein 4 isoform X3

      Conserved Domains (2) summary
      pfam09457
      Location:494 → 534
      RBD-FIP; FIP domain
      cl03075
      Location:326 → 410
      GrpE; nucleotide exchange factor GrpE

    4. XM_063269073.1 → XP_063125143.1  rab11 family-interacting protein 4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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