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    Svop SV2 related protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171442, updated on 27-Nov-2024

    Summary

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    Symbol
    Svopprovided by RGD
    Full Name
    SV2 related proteinprovided by RGD
    Primary source
    RGD:620277
    See related
    EnsemblRapid:ENSRNOG00000000693 AllianceGenome:RGD:620277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SVOP (SV2 related protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 210.8) and Kidney (RPKM 21.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Svop in Genome Data Viewer
    Location:
    12q16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48191549..48251185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42530991..42589381)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48292272..48351974)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene legumain pseudogene Neighboring gene ubiquitin specific peptidase 30 Neighboring gene D-amino-acid oxidase Neighboring gene slingshot protein phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles. Janz R, et al. J Neurosci, 1998 Nov 15. PMID 9801366, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synaptic vesicle 2-related protein
    Names
    synaptic vesicle 2-related protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134404.4 → NP_599231.3  synaptic vesicle 2-related protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q9Z2I7
      UniProtKB/TrEMBL
      A0A8L2PZP2, A6J214
      Related
      ENSRNOP00000000874.5, ENSRNOT00000000874.6
      Conserved Domains (1) summary
      cd17441
      Location:87 → 509
      MFS_SVOP; Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48191549..48251185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769316.4 → XP_008767538.1  synaptic vesicle 2-related protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZX3, A0A8L2PZP2
      Related
      ENSRNOP00000071220.1, ENSRNOT00000084511.3
      Conserved Domains (2) summary
      cd06174
      Location:87 → 508
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12 → 518
      2A0119; cation transport protein

    2. XM_063271030.1 → XP_063127100.1  synaptic vesicle 2-related protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2I7.1 GenPept UniProtKB/Swiss-Prot:Q9Z2I7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials