Enah ENAH, actin regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Enahprovided by RGD
Official Full Name: ENAH, actin regulatorprovided by RGD
Primary source: RGD:1307666
See related: EnsemblRapid:ENSRNOG00000031934 AllianceGenome:RGD:1307666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity; WW domain binding activity; and profilin binding activity. Involved in postsynaptic cytoskeleton organization. Is active in GABA-ergic synapse and postsynapse. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 290.1), Heart (RPKM 226.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (96149437..96269841, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (93617747..93738119, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (100297421..100415335, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tetramerization domain (TD) at the C-termini of enabled/VASP proteins conferred the observed selectivity.
Title: Selectivity in subunit composition of Ena/VASP tetramers.
Mena is associated with active Rac1 in cardiomyocytes. Knockdown of Mena increased Rac1 activity, connexin43 expression and localization.
Title: Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE112154 (e-PCR)
- UniSTS:246067

BF410035 (e-PCR)
- UniSTS:246668

AU047203 (e-PCR)
- UniSTS:110739

RH134481 (e-PCR)
- UniSTS:217761

Enah (e-PCR), detects polymorphism
- UniSTS:258254

BF405107 (e-PCR)
- UniSTS:247793

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization-dependent cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization-dependent cell motility	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein enabled homolog

Names: enabled homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012150.2 → NP_001012150.1 protein enabled homolog isoform 2

See identical proteins and their annotated locations for NP_001012150.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6JGK5, Q5XHX3

Related

ENSRNOP00000112465.1, ENSRNOT00000171057.1

Conserved Domains (3) summary

cd01207
Location:25 → 132

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam06012
Location:430 → 500

DUF908; Domain of Unknown Function (DUF908)

pfam08776
Location:489 → 522

VASP_tetra; VASP tetramerization domain
NM_001401377.1 → NP_001388306.1 protein enabled homolog isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I5ZT50, A6JGK6

Related

ENSRNOP00000081655.1, ENSRNOT00000098544.2
NM_001415736.1 → NP_001402665.1 protein enabled homolog isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOP00000081404.1, ENSRNOT00000097600.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

96149437..96269841 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272503.1 → XP_063128573.1 protein enabled homolog isoform X11
XM_063272502.1 → XP_063128572.1 protein enabled homolog isoform X10
XM_063272500.1 → XP_063128570.1 protein enabled homolog isoform X9
XM_063272497.1 → XP_063128567.1 protein enabled homolog isoform X6

Related

ENSRNOP00000109230.1, ENSRNOT00000153721.1
XM_063272494.1 → XP_063128564.1 protein enabled homolog isoform X2

UniProtKB/TrEMBL

A0A8I5Y4S4

Related

ENSRNOP00000076584.1, ENSRNOT00000109962.2
XM_063272499.1 → XP_063128569.1 protein enabled homolog isoform X8
XM_063272498.1 → XP_063128568.1 protein enabled homolog isoform X7

UniProtKB/TrEMBL

A0A0G2K6I4

Related

ENSRNOP00000073827.2, ENSRNOT00000085188.3
XM_063272496.1 → XP_063128566.1 protein enabled homolog isoform X5
XM_039090926.2 → XP_038946854.1 protein enabled homolog isoform X3

UniProtKB/TrEMBL

A0A8I6G5W6

Conserved Domains (4) summary

PLN03209
Location:361 → 537

PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional

cd01207
Location:25 → 132

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:767 → 801

VASP_tetra; VASP tetramerisation domain

cd22185
Location:619 → 645

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_063272493.1 → XP_063128563.1 protein enabled homolog isoform X1
XM_063272506.1 → XP_063128576.1 protein enabled homolog isoform X15
XM_063272495.1 → XP_063128565.1 protein enabled homolog isoform X4
XM_063272505.1 → XP_063128575.1 protein enabled homolog isoform X14
XM_039090933.2 → XP_038946861.1 protein enabled homolog isoform X12

Conserved Domains (2) summary

pfam08776
Location:405 → 439

VASP_tetra; VASP tetramerisation domain

cd22185
Location:236 → 262

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_063272504.1 → XP_063128574.1 protein enabled homolog isoform X13