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    Jakmip1 janus kinase and microtubule interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305434, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Jakmip1provided by RGD
    Official Full Name
    janus kinase and microtubule interacting protein 1provided by RGD
    Primary source
    RGD:1562401
    See related
    EnsemblRapid:ENSRNOG00000004998 AllianceGenome:RGD:1562401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Marlin1; Marlin-1
    Summary
    Predicted to enable GABA receptor binding activity; RNA binding activity; and kinesin binding activity. Predicted to be involved in cognition. Located in microtubule cytoskeleton. Orthologous to human JAKMIP1 (janus kinase and microtubule interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 119.2), Thymus (RPKM 89.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jakmip1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (77871034..77991566, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (73646299..73766830, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (78403448..78523108, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene EvC ciliary complex subunit 1 Neighboring gene collapsin response mediator protein 1 Neighboring gene glyoxalase 1, pseudogene 1 Neighboring gene similar to human chromosome 4 open reading frame 50 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134481775

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Vidal RL, et al. Mol Cell Neurosci, 2012 Aug. PMID 22828129
    2. Cellular and subcellular localization of Marlin-1 in the brain. Vidal RL, et al. BMC Neurosci, 2009 Apr 22. PMID 19386132, Free PMC Article
    3. Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors. Vidal RL, et al. J Cell Biochem, 2008 Feb 15. PMID 17668444
    4. Marlin-1, a novel RNA-binding protein associates with GABA receptors. Couve A, et al. J Biol Chem, 2004 Apr 2. PMID 14718537
    5. Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. Vidal RL, et al. Mol Cell Neurosci, 2007 Jul. PMID 17532644

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level.
      Title: Cellular and subcellular localization of Marlin-1 in the brain.
    2. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues.
      Title: Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors.
    3. Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers.
      Title: Marlin-1, a novel RNA-binding protein associates with GABA receptors.
    4. RNA interference of Marlin-1 in vivo results in abnormal migration and abnormal morphology of newborn pyramidal neurons during the formation of the cortex.
      Title: RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125191, MGC125215

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    janus kinase and microtubule-interacting protein 1
    Names
    multiple alpha helices and RNA-linker protein 1
    multiple coiled-coil GABABR1-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033894.1 → NP_001029066.1  janus kinase and microtubule-interacting protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001029066.1

      Status: VALIDATED

      Source sequence(s)
      BC104677
      UniProtKB/Swiss-Prot
      Q3SWS9
      Conserved Domains (2) summary
      TIGR02169
      Location:6 → 363
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam16034
      Location:416 → 604
      JAKMIP_CC3; JAKMIP CC3 domain

    2. NM_001401057.1 → NP_001387986.1  janus kinase and microtubule-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOP00000006771.6, ENSRNOT00000006771.6

    3. NM_001401058.1 → NP_001387987.1  janus kinase and microtubule-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8L2Q2V8

    4. NM_001401059.1 → NP_001387988.1  janus kinase and microtubule-interacting protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    5. NM_001401060.1 → NP_001387989.1  janus kinase and microtubule-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOP00000103569.1, ENSRNOT00000125060.1

    6. NM_001401062.1 → NP_001387991.1  janus kinase and microtubule-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q3SWS9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      77871034..77991566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273143.1 → XP_063129213.1  janus kinase and microtubule-interacting protein 1 isoform X5

    2. XM_017599204.3 → XP_017454693.1  janus kinase and microtubule-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A6IJW6

    3. XM_017599201.3 → XP_017454690.1  janus kinase and microtubule-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A6IJW6
      Related
      ENSRNOP00000105142.1, ENSRNOT00000150746.1

    4. XM_039091951.2 → XP_038947879.1  janus kinase and microtubule-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A6IJW6
      Conserved Domains (2) summary
      TIGR02169
      Location:6 → 363
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam16034
      Location:416 → 612
      JAKMIP_CC3; JAKMIP CC3 domain

    5. XM_017599199.3 → XP_017454688.1  janus kinase and microtubule-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6IJW6
      Conserved Domains (2) summary
      TIGR02169
      Location:6 → 363
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam16034
      Location:416 → 612
      JAKMIP_CC3; JAKMIP CC3 domain

    6. XM_039091949.2 → XP_038947877.1  janus kinase and microtubule-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6IJW6
      Conserved Domains (2) summary
      TIGR02169
      Location:6 → 363
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam16034
      Location:416 → 612
      JAKMIP_CC3; JAKMIP CC3 domain

    7. XM_039091948.2 → XP_038947876.1  janus kinase and microtubule-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6IJW6
      Conserved Domains (2) summary
      TIGR02169
      Location:6 → 363
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam16034
      Location:416 → 612
      JAKMIP_CC3; JAKMIP CC3 domain

    8. XM_063273146.1 → XP_063129216.1  janus kinase and microtubule-interacting protein 1 isoform X8

      Related
      ENSRNOP00000084871.1, ENSRNOT00000106540.2

    9. XM_039091952.2 → XP_038947880.1  janus kinase and microtubule-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZYV3
      Conserved Domains (2) summary
      TIGR02168
      Location:357 → 634
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16034
      Location:208 → 404
      JAKMIP_CC3; JAKMIP CC3 domain

    10. XM_039091953.2 → XP_038947881.1  janus kinase and microtubule-interacting protein 1 isoform X10

      Conserved Domains (2) summary
      TIGR02168
      Location:182 → 459
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16034
      Location:33 → 229
      JAKMIP_CC3; JAKMIP CC3 domain

    11. XM_063273144.1 → XP_063129214.1  janus kinase and microtubule-interacting protein 1 isoform X6

      Related
      ENSRNOP00000107455.1, ENSRNOT00000172701.1

    12. XM_063273147.1 → XP_063129217.1  janus kinase and microtubule-interacting protein 1 isoform X9

      UniProtKB/Swiss-Prot
      Q3SWS9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SWS9.1 GenPept UniProtKB/Swiss-Prot:Q3SWS9

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