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    Washc2c WASH complex subunit 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297530, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Washc2cprovided by RGD
    Official Full Name
    WASH complex subunit 2Cprovided by RGD
    Primary source
    RGD:735230
    See related
    EnsemblRapid:ENSRNOG00000011653 AllianceGenome:RGD:735230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam21; Fam21c; Washc2; NP61201
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; negative regulation of barbed-end actin filament capping; and protein localization to endosome. Predicted to be located in cytosol; endosome; and nucleolus. Predicted to be part of WASH complex. Predicted to be active in early endosome. Orthologous to human WASHC2A (WASH complex subunit 2A) and WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 299.6), Brain (RPKM 274.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Washc2c in Genome Data Viewer
    Location:
    4q42
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150912863..150998301)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149267851..149325850)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148139512..148197363)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene plexin D1 Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene small RNA binding exonuclease protection factor La like 1 Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene ribosomal protein L23A like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Helfer E, et al. Biol Cell, 2013 May. PMID 23331060
    2. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. McGough IJ, et al. J Cell Sci, 2014 Nov 15. PMID 25278552, Free PMC Article
    3. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Harbour ME, et al. Biochem J, 2012 Feb 15. PMID 22070227
    4. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Jia D, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498093, Free PMC Article
    5. A FAM21-containing WASH complex regulates retromer-dependent sorting. Gomez TS, et al. Dev Cell, 2009 Nov. PMID 19922874, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retromer complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of WASH complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WASH complex subunit 2
    Names
    WASH complex subunit FAM21
    family with sequence similarity 21, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199207.2 → NP_954677.2  WASH complex subunit 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q80X08
      Related
      ENSRNOP00000112244.1, ENSRNOT00000147561.1
      Conserved Domains (1) summary
      pfam15255
      Location:946 → 1068
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      150912863..150998301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285891.1 → XP_063141961.1  WASH complex subunit 2 isoform X7

      Related
      ENSRNOP00000088489.2, ENSRNOT00000092689.3

    2. XM_039107431.2 → XP_038963359.1  WASH complex subunit 2 isoform X8

      UniProtKB/Swiss-Prot
      Q80X08
      Conserved Domains (1) summary
      pfam15255
      Location:924 → 1046
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    3. XM_039107428.2 → XP_038963356.1  WASH complex subunit 2 isoform X5

      UniProtKB/Swiss-Prot
      Q80X08
      Conserved Domains (1) summary
      pfam15255
      Location:946 → 1068
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    4. XM_063285890.1 → XP_063141960.1  WASH complex subunit 2 isoform X6

    5. XM_006237147.5 → XP_006237209.1  WASH complex subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q80X08
      UniProtKB/TrEMBL
      A0A8I6ADQ6
      Related
      ENSRNOP00000015620.7, ENSRNOT00000015620.8
      Conserved Domains (1) summary
      pfam15255
      Location:925 → 1043
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    6. XM_039107425.2 → XP_038963353.1  WASH complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q80X08
      Conserved Domains (1) summary
      pfam15255
      Location:945 → 1067
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    7. XM_006237149.5 → XP_006237211.1  WASH complex subunit 2 isoform X4

      UniProtKB/Swiss-Prot
      Q80X08
      UniProtKB/TrEMBL
      A0A8I6AM40
      Related
      ENSRNOP00000096602.1, ENSRNOT00000100585.2
      Conserved Domains (1) summary
      pfam15255
      Location:903 → 1030
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    8. XM_039107426.2 → XP_038963354.1  WASH complex subunit 2 isoform X3

      UniProtKB/Swiss-Prot
      Q80X08
      Related
      ENSRNOP00000104973.1, ENSRNOT00000163668.1
      Conserved Domains (1) summary
      pfam15255
      Location:925 → 1047
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X08.1 GenPept UniProtKB/Swiss-Prot:Q80X08

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