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    Akap9 A-kinase anchoring protein 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246150, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Akap9provided by RGD
    Official Full Name
    A-kinase anchoring protein 9provided by RGD
    Primary source
    RGD:620833
    See related
    EnsemblRapid:ENSRNOG00000026319 AllianceGenome:RGD:620833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gisp; CG-NAP; Yotiao
    Summary
    Enables protein kinase A regulatory subunit binding activity. Involved in negative regulation of adenylate cyclase activity and response to electrical stimulus. Located in dendritic branch; neuronal cell body; and synaptic membrane. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in long QT syndrome 11. Orthologous to human AKAP9 (A-kinase anchoring protein 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 257.0), Heart (RPKM 188.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap9 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31011475..31147338, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30056738..30192716, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27195346..27331582, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486558 Neighboring gene cytochrome P450, family 51 Neighboring gene uncharacterized histidine-rich protein DDB_G0274557-like Neighboring gene uncharacterized LOC134486559 Neighboring gene mitochondrial transcription termination factor 1 Neighboring gene leucine-rich repeats and death domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis. Wu S, et al. FASEB J, 2021 Oct. PMID 34569663
    2. GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation. Kantamneni S, et al. Neurosci Lett, 2009 Mar 13. PMID 19154774, Free PMC Article
    3. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Westphal RS, et al. Science, 1999 Jul 2. PMID 10390370
    4. Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. Taskén KA, et al. J Biol Chem, 2001 Jun 22. PMID 11285255
    5. Repeated electroconvulsive shock treatment increases the expression of A kinase anchoring proteins in the rat hippocampus. Lee YI, et al. Neurosci Lett, 2004 Jan 30. PMID 14732469

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
      Title: AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
    2. These data suggest that GISP is a novel neuronal SUMO substrate whose SUMOylation status is modulated by neuronal activity.
      Title: Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.
    3. InsP3R1 forms a complex with AKAP450 and PKAIIbeta, localized in the Golgi apparatus of cerebellar granule cells.
      Title: Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells.
    4. GISP acts as a negative regulator of TSG101-dependent lysosomal degradation and plays an important role in determining the availability of neurotransmitter receptors.
      Title: GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
    5. These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability.
      Title: GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
    6. GISP is involved in the forward trafficking and stabilization of functional GABA(B)Rs.
      Title: GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A regulatory subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of centrosome location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in subapical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 9
    Names
    A kinase (PRKA) anchor protein (yotiao) 9
    A kinase (PRKA) anchor protein 9
    GABA-B receptor-interacting scaffolding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037093.2 → NP_001032170.2  A-kinase anchor protein 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AIG6, F1LPB4
      Related
      ENSRNOP00000010118.5, ENSRNOT00000010118.8
      Conserved Domains (2) summary
      TIGR02168
      Location:131 → 860
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:3569 → 3650
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      31011475..31147338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285532.1 → XP_063141602.1  A-kinase anchor protein 9 isoform X12

    2. XM_006236025.4 → XP_006236087.1  A-kinase anchor protein 9 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AIG6, A0A8I6GHX5
      Related
      ENSRNOP00000089245.2, ENSRNOT00000111753.2
      Conserved Domains (2) summary
      TIGR02168
      Location:131 → 860
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:3614 → 3695
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    3. XM_063285527.1 → XP_063141597.1  A-kinase anchor protein 9 isoform X6

    4. XM_017592446.3 → XP_017447935.1  A-kinase anchor protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIG6

    5. XM_063285531.1 → XP_063141601.1  A-kinase anchor protein 9 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZWI9
      Related
      ENSRNOP00000084102.1, ENSRNOT00000114783.2

    6. XM_063285530.1 → XP_063141600.1  A-kinase anchor protein 9 isoform X10

    7. XM_006236023.5 → XP_006236085.1  A-kinase anchor protein 9 isoform X5

      See identical proteins and their annotated locations for XP_006236085.1

      UniProtKB/TrEMBL
      A0A8I6AIG6, A6K272
      Conserved Domains (2) summary
      TIGR02168
      Location:149 → 878
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:3632 → 3713
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    8. XM_017592447.3 → XP_017447936.1  A-kinase anchor protein 9 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K548, A0A8I6AIG6
      Related
      ENSRNOP00000073290.1, ENSRNOT00000090751.3

    9. XM_063285528.1 → XP_063141598.1  A-kinase anchor protein 9 isoform X9

    10. XM_017592448.3 → XP_017447937.1  A-kinase anchor protein 9 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AIG6

    11. XM_008762686.4 → XP_008760908.1  A-kinase anchor protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIG6
      Conserved Domains (2) summary
      TIGR02168
      Location:149 → 878
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:3657 → 3738
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    12. XM_008762685.4 → XP_008760907.1  A-kinase anchor protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIG6
      Conserved Domains (2) summary
      TIGR02168
      Location:149 → 878
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:3670 → 3751
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    13. XM_063285533.1 → XP_063141603.1  A-kinase anchor protein 9 isoform X13

    Nucleotide Protein Strain
    Heading Accession and Version

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