Slc44a2 solute carrier family 44 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc44a2provided by RGD
Official Full Name: solute carrier family 44 member 2provided by RGD
Primary source: RGD:1309680
See related: EnsemblRapid:ENSRNOG00000031824 AllianceGenome:RGD:1309680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309680
Summary: Predicted to enable choline transmembrane transporter activity and ethanolamine transmembrane transporter activity. Predicted to be involved in several processes, including choline transport; ethanolamine transport; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in mitochondrial outer membrane and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC44A2 (solute carrier family 44 member 2 (CTL2 blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 404.4), Lung (RPKM 336.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28147023..28181496)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19870867..19905345)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22351277..22385869)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF410447 (e-PCR)
- UniSTS:246829

RH135148 (e-PCR)
- UniSTS:218425

RH129061 (e-PCR)
- UniSTS:212369

35.MMHAP10FD5.seq (e-PCR)
- UniSTS:124126

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
NOT enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanolamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ethanolamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in choline transport	IEA Inferred from Electronic Annotation more info
NOT involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in ethanolamine transport	IEA Inferred from Electronic Annotation more info
involved_in ethanolamine transport	ISO Inferred from Sequence Orthology more info
involved_in ethanolamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in organic cation transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: choline transporter-like protein 2

Names: solute carrier family 44 (choline transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.