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    Alg9 ALG9, alpha-1,2-mannosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367083, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Alg9provided by RGD
    Official Full Name
    ALG9, alpha-1,2-mannosyltransferaseprovided by RGD
    Primary source
    RGD:1311272
    See related
    EnsemblRapid:ENSRNOG00000010877 AllianceGenome:RGD:1311272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dibd1
    Summary
    Predicted to enable dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity and dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 52.2), Kidney (RPKM 36.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg9 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60013429..60085159)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51117057..51188790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55202140..55265478)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 2 Neighboring gene cilia and flagella associated protein 68 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene uncharacterized LOC134480165 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene protein phosphatase 2 scaffold subunit A beta Neighboring gene salt-inducible kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase ALG9
    Names
    asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)
    asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase)
    asparagine-linked glycosylation 9 protein
    asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog
    disrupted in bipolar affective disorder 1
    NP_001381277.1
    NP_001381278.1
    XP_038937793.1
    XP_038937794.1
    XP_038937795.1
    XP_038937796.1
    XP_038937797.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394348.1 → NP_001381277.1  alpha-1,2-mannosyltransferase ALG9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GCZ5, D3ZCW5
      Related
      ENSRNOP00000085516.1, ENSRNOT00000098102.2
      Conserved Domains (1) summary
      pfam03901
      Location:68 → 490
      Glyco_transf_22; Alg9-like mannosyltransferase family

    2. NM_001394349.1 → NP_001381278.1  alpha-1,2-mannosyltransferase ALG9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y6Z5, A0A8I6GCZ5
      Related
      ENSRNOP00000078122.1, ENSRNOT00000115652.2
      Conserved Domains (1) summary
      pfam03901
      Location:25 → 447
      Glyco_transf_22; Alg9-like mannosyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60013429..60085159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081868.2 → XP_038937796.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. XM_039081865.2 → XP_038937793.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    3. XM_039081866.2 → XP_038937794.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    4. XM_039081869.2 → XP_038937797.1  alpha-1,2-mannosyltransferase ALG9 isoform X2

      Conserved Domains (1) summary
      cl21590
      Location:1 → 311
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    5. XM_039081867.2 → XP_038937795.1  alpha-1,2-mannosyltransferase ALG9 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:51 → 377
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109000.1: Suppressed sequence

      Description
      NM_001109000.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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