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    Plscr2 phospholipid scramblase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315883, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plscr2provided by RGD
    Official Full Name
    phospholipid scramblase 2provided by RGD
    Primary source
    RGD:1359107
    See related
    EnsemblRapid:ENSRNOG00000064984 AllianceGenome:RGD:1359107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in cellular response to lipopolysaccharide and plasma membrane phospholipid scrambling. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 768.8), Lung (RPKM 219.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plscr2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (101689202..101725726)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (92809422..92845947)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (99650351..99725514)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094226 Neighboring gene uncharacterized LOC102550510 Neighboring gene phospholipid scramblase 1 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene uncharacterized LOC134480085 Neighboring gene phospholipid scramblase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1. Yu A, et al. J Biol Chem, 2003 Mar 14. PMID 12509439
    2. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Lu B, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590392
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid scramblase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014094.2 → NP_001014116.1  phospholipid scramblase 2 isoform 1

      See identical proteins and their annotated locations for NP_001014116.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AEL2, Q6AYD7
      Related
      ENSRNOP00000091509.2, ENSRNOT00000116380.2
      Conserved Domains (2) summary
      pfam03803
      Location:88 → 308
      Scramblase; Scramblase
      pfam11029
      Location:2 → 99
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    2. NM_001423657.1 → NP_001410586.1  phospholipid scramblase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      Related
      ENSRNOP00000086482.2, ENSRNOT00000108295.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      101689202..101725726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081540.2 → XP_038937468.1  phospholipid scramblase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYB5, A0A8I6AEL2
      Conserved Domains (1) summary
      pfam03803
      Location:86 → 306
      Scramblase

    2. XM_063265573.1 → XP_063121643.1  phospholipid scramblase 2 isoform X3

    3. XM_063265572.1 → XP_063121642.1  phospholipid scramblase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3V8, A6I240

    4. XM_063265571.1 → XP_063121641.1  phospholipid scramblase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3V8, A6I240
    Nucleotide Protein Strain
    Heading Accession and Version

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