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    Zfx zinc finger protein X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367832, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfxprovided by RGD
    Official Full Name
    zinc finger protein X-linkedprovided by RGD
    Primary source
    RGD:1562664
    See related
    EnsemblRapid:ENSRNOG00000005624 AllianceGenome:RGD:1562664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562664
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 157.2), Lung (RPKM 134.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfx in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62798483..62847068, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58804690..58853155, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63158368..63204971, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Supt20h like 1 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene small nuclear ribonucleoprotein polypeptide F, pseudogene 2 Neighboring gene uncharacterized LOC134484053 Neighboring gene uncharacterized LOC134484164 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Luoh SW, et al. Development, 1997 Jun. PMID 9187153
    2. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within parental behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger X-chromosomal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109017.3 → NP_001102487.2  zinc finger X-chromosomal protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A096MJI1
      Related
      ENSRNOP00000112832.1, ENSRNOT00000149886.1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      62798483..62847068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280179.1 → XP_063136249.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/TrEMBL
      A0A096MJV6

    2. XM_006257030.5 → XP_006257092.1  zinc finger X-chromosomal protein isoform X1

      See identical proteins and their annotated locations for XP_006257092.1

      UniProtKB/TrEMBL
      A0A096MJI1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    3. XM_039099945.2 → XP_038955873.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/TrEMBL
      A0A096MJI1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    4. XM_063280177.1 → XP_063136247.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/TrEMBL
      A0A096MJV6
      Related
      ENSRNOP00000068277.2, ENSRNOT00000076175.4

    5. XM_063280178.1 → XP_063136248.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/TrEMBL
      A0A096MJV6

    6. XM_039099947.2 → XP_038955875.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/TrEMBL
      A0A096MJI1, A0A096MJV6
      Conserved Domains (6) summary
      COG5048
      Location:487 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:663 → 685
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 354
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:677 → 701
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:321 → 401
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    7. XM_039099946.2 → XP_038955874.1  zinc finger X-chromosomal protein isoform X2

      UniProtKB/TrEMBL
      A0A096MJI1
      Related
      ENSRNOP00000068521.3, ENSRNOT00000076765.3
      Conserved Domains (6) summary
      COG5048
      Location:490 → 627
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:666 → 688
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 351
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:680 → 704
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:374 → 404
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    8. XM_006257032.5 → XP_006257094.1  zinc finger X-chromosomal protein isoform X1

      See identical proteins and their annotated locations for XP_006257094.1

      UniProtKB/TrEMBL
      A0A096MJI1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    9. XM_008773265.4 → XP_008771487.1  zinc finger X-chromosomal protein isoform X1

      See identical proteins and their annotated locations for XP_008771487.1

      UniProtKB/TrEMBL
      A0A096MJI1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    Nucleotide Protein Strain
    Heading Accession and Version

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