ZNF765 zinc finger protein 765 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF765provided by HGNC
Official Full Name: zinc finger protein 765provided by HGNC
Primary source: HGNC:HGNC:25092
See related: Ensembl:ENSG00000196417 AllianceGenome:HGNC:25092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary (RPKM 4.5), testis (RPKM 2.5) and 25 other tissues See more
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Genomic context

Location:: 19q13.42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (53395149..53427321)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (56474647..56506876)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (53898402..53930574)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
Title: IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH122965 (e-PCR)
- UniSTS:135262

RH118661 (e-PCR)
- UniSTS:138154

Readthrough ZNF765-ZNF761

Readthrough gene: ZNF765-ZNF761, Included gene: ZNF525, Included gene: ZNF761

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 765

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040185.3 → NP_001035275.1 zinc finger protein 765 isoform 1

See identical proteins and their annotated locations for NP_001035275.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC022137, CD656338

Consensus CDS

CCDS46171.1

UniProtKB/Swiss-Prot

A8MYG0, B4DF18, B7ZAI5, B9EIL1, Q7L2R6, Q9BV49

Related

ENSP00000379689.3, ENST00000396408.8

Conserved Domains (5) summary

smart00349
Location:8 → 48

KRAB; krueppel associated box

COG5048
Location:325 → 477

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:8 → 47

KRAB; KRAB box

pfam13465
Location:314 → 338

zf-H2C2_2; Zinc-finger double domain
NM_001350495.2 → NP_001337424.1 zinc finger protein 765 isoform 2

Status: VALIDATED

Source sequence(s)

AC022137

Conserved Domains (3) summary

COG5048
Location:272 → 424

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:276 → 296

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:204 → 229

zf-H2C2_2; Zinc-finger double domain