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    ZSCAN23 zinc finger and SCAN domain containing 23 [ Homo sapiens (human) ]

    Gene ID: 222696, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZSCAN23provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 23provided by HGNC
    Primary source
    HGNC:HGNC:21193
    See related
    Ensembl:ENSG00000187987 AllianceGenome:HGNC:21193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF390; ZNF453; dJ29K1.3; dJ29K1.3.1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZSCAN23 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28421400..28443491, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28290130..28314932, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28400432..28411268, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 968, pseudogene Neighboring gene RNA, U2 small nuclear 45, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28384184-28384684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28384685-28385185 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:28390954-28392153 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28411067-28411577 Neighboring gene COX11 pseudogene 1 Neighboring gene olfactory receptor family 2 subfamily E member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ99276, MGC126606, MGC126608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 23
    Names
    zinc finger protein 390
    zinc finger protein 453

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012455.2NP_001012458.1  zinc finger and SCAN domain-containing protein 23

      See identical proteins and their annotated locations for NP_001012458.1

      Status: VALIDATED

      Source sequence(s)
      AL833347, BX283350, Z98745
      Consensus CDS
      CCDS47393.1
      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9
      Related
      ENSP00000289788.4, ENST00000289788.5
      Conserved Domains (6) summary
      smart00431
      Location:44156
      SCAN; leucine rich region
      COG5048
      Location:215384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:251271
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:249271
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:45132
      SCAN; SCAN domain
      pfam13465
      Location:264288
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28421400..28443491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418384.1XP_047274340.1  zinc finger and SCAN domain-containing protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9

    RNA

    1. XR_007059226.1 RNA Sequence

    2. XR_007059223.1 RNA Sequence

    3. XR_007059224.1 RNA Sequence

    4. XR_007059225.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      28290130..28314932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354667.1XP_054210642.1  zinc finger and SCAN domain-containing protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q3MJ62, Q96KV9

    RNA

    1. XR_008487284.1 RNA Sequence

    2. XR_008487281.1 RNA Sequence

    3. XR_008487282.1 RNA Sequence

    4. XR_008487283.1 RNA Sequence