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    TPD52 tumor protein D52 [ Homo sapiens (human) ]

    Gene ID: 7163, updated on 10-Dec-2024

    Summary

    Official Symbol
    TPD52provided by HGNC
    Official Full Name
    tumor protein D52provided by HGNC
    Primary source
    HGNC:HGNC:12005
    See related
    Ensembl:ENSG00000076554 MIM:604068; AllianceGenome:HGNC:12005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D52; N8L; PC-1; PrLZ; hD52
    Summary
    Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon (RPKM 43.8), prostate (RPKM 36.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TPD52 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80031082..80171564, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80462421..80603125, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80943317..81083799, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927040 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene U7 small nuclear RNA Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19315 Neighboring gene uncharacterized LOC124901966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19316 Neighboring gene TPD52-MRPS28 readthrough Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene VISTA enhancer hs1305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80894241-80894806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:80909347-80909896 Neighboring gene Sharpr-MPRA regulatory region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19317 Neighboring gene Sharpr-MPRA regulatory region 3052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27553 Neighboring gene uncharacterized LOC105375919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19318 Neighboring gene uncharacterized LOC105375918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81013977-81014477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19319 Neighboring gene uncharacterized LOC105375920 Neighboring gene RNA, 7SL, cytoplasmic 41, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19321 Neighboring gene microRNA 5708

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1254 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Interactions

    General gene information

    Readthrough TPD52-MRPS28

    Readthrough gene: TPD52-MRPS28, Included gene: MRPS28

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    tumor protein D52
    Names
    prostate and colon associated protein
    prostate leucine zipper
    protein N8
    NP_001020423.1
    NP_001020424.1
    NP_001274069.1
    NP_001274071.1
    NP_001274072.1
    NP_001274073.1
    NP_001374708.1
    NP_001374709.1
    NP_005070.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025252.3 → NP_001020423.1  tumor protein D52 isoform 1

      See identical proteins and their annotated locations for NP_001020423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (1, also known as PrLZ-224) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499327, U18914
      Consensus CDS
      CCDS34912.1
      UniProtKB/Swiss-Prot
      B7Z414, C9J502, D0UFD1, D0UFD2, D0UFD3, D0UFD4, D0UFD5, E5RKB4, P55327, Q13056, Q53EK8, Q6FGP3, Q6FGS3, Q86YZ2, Q9UCX8
      Related
      ENSP00000368391.3, ENST00000379097.7
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 210
      TPD52; Tumour protein D52 family
    2. NM_001025253.3 → NP_001020424.1  tumor protein D52 isoform 2

      See identical proteins and their annotated locations for NP_001020424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, compared to variant 4. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC009686, AK295468, BU071387, CB128067, DA079836, DC331087, U18914
      Consensus CDS
      CCDS47879.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429915.1, ENST00000518937.6
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 193
      TPD52; Tumour protein D52 family
    3. NM_001287140.2 → NP_001274069.1  tumor protein D52 isoform 4

      See identical proteins and their annotated locations for NP_001274069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4, also known as PrLZ-247).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499324, U18914
      Consensus CDS
      CCDS75759.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429309.1, ENST00000520527.5
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 233
      TPD52; Tumour protein D52 family
    4. NM_001287142.2 → NP_001274071.1  tumor protein D52 isoform 5

      See identical proteins and their annotated locations for NP_001274071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (5, also known as PrLZ-238) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499325, U18914
      Consensus CDS
      CCDS75757.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000410222.2, ENST00000448733.3
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 224
      TPD52; Tumour protein D52 family
    5. NM_001287143.2 → NP_001274072.1  tumor protein D52 isoform 6

      See identical proteins and their annotated locations for NP_001274072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (6, also known as PrLZ-233) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499326, U18914
      Consensus CDS
      CCDS75758.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429351.1, ENST00000517427.5
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 219
      TPD52; Tumour protein D52 family
    6. NM_001287144.2 → NP_001274073.1  tumor protein D52 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, it lacks two alternate in-frame exons in the central coding region, and it uses an alternate splice site that results in an early stop codon, compared to variant 4. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      BU071387, CB128067, DA079836, DA409017, DC331087, U18914
      UniProtKB/Swiss-Prot
      P55327
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 145
      TPD52; Tumour protein D52 family
    7. NM_001387779.1 → NP_001374708.1  tumor protein D52 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC009686
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 146
      TPD52; tumor protein D52 family
    8. NM_001387780.1 → NP_001374709.1  tumor protein D52 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC009686
      Conserved Domains (1) summary
      pfam04201
      Location:20 → 154
      TPD52; tumor protein D52 family
    9. NM_005079.4 → NP_005070.1  tumor protein D52 isoform 3

      See identical proteins and their annotated locations for NP_005070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it lacks two alternate in-frame exons in the central coding region, compared to variant 4. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC331087, U18914
      Consensus CDS
      CCDS55249.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000368390.4, ENST00000379096.9
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 170
      TPD52; tumor protein D52 family

    RNA

    1. NR_105033.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) includes an additional exon in the central region, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499328, U18914
    2. NR_105034.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains an alternate 5' terminal exon and lacks three internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DB505575, DC331087, U18914
    3. NR_105035.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DA199944, DC331087, U18914
    4. NR_105036.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 4. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC009686, AK308983, BU071387, CB128067, DA079836, DA665049, U18914
    5. NR_105037.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because it lacks a supported open reading frame.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DA665049, DA921955, U18914
    6. NR_170693.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009686
    7. NR_170694.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009686

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      80031082..80171564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      80462421..80603125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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