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    ADCY3 adenylate cyclase 3 [ Homo sapiens (human) ]

    Gene ID: 109, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADCY3provided by HGNC
    Official Full Name
    adenylate cyclase 3provided by HGNC
    Primary source
    HGNC:HGNC:234
    See related
    Ensembl:ENSG00000138031 MIM:600291; AllianceGenome:HGNC:234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AC3; AC-III; BMIQ19
    Summary
    This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 27.7), ovary (RPKM 14.8) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ADCY3 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24819169..24920237, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24853918..24954979, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25042038..25143106, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25045379-25045923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048335-25048894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048895-25049453 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene uncharacterized LOC105377626 Neighboring gene Sharpr-MPRA regulatory region 9030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25057468-25058391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25056543-25057467 Neighboring gene centromere protein O Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25097035-25097779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25121605-25122524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126133-25126634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126635-25127134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15436 Neighboring gene uncharacterized LOC124907742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25149032-25149746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15437 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:25180226-25181180 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene ribosomal protein S13 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. Nordman S, et al. Int J Obes (Lond), 2008 Mar. PMID 17895882
    2. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. Yang B, et al. Biochem Biophys Res Commun, 1999 Jan 27. PMID 9920776
    3. Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes. Grarup N, et al. Nat Genet, 2018 Feb. PMID 29311636, Free PMC Article
    4. Loss-of-function mutations in ADCY3 cause monogenic severe obesity. Saeed S, et al. Nat Genet, 2018 Feb. PMID 29311637
    5. Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial. Goni L, et al. Nutrients, 2018 Jun 19. PMID 29921800, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
      Title: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
    2. Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
      Title: Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
    3. Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.
      Title: Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.
    4. Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.
      Title: Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.
    5. ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.
      Title: ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.
    6. ADCY3 is an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.
      Title: Loss-of-function mutations in ADCY3 cause monogenic severe obesity.
    7. An enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts.
      Title: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
    8. MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons; obesity-associated MC4R mutations impair ciliary localization and inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight.
      Title: Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
    9. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.
      Title: Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.
    10. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops.
      Title: Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
    MedGen: C4693522 OMIM: 617885 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog
    A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
    EBI GWAS Catalog
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    EBI GWAS Catalog
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    EBI GWAS Catalog
    Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analysis identifies common variants associated with body mass index in east Asians.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
    Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
    Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
    Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome reaction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to forskolin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory learning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of smell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in single fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 3
    Names
    ATP pyrophosphate-lyase 3
    adenylate cyclase type III
    adenylate cyclase, olfactive type
    adenylyl cyclase 3
    adenylyl cyclase, type III
    NP_001307542.1
    NP_001364057.1
    NP_001364058.1
    NP_001364059.1
    NP_001364060.1
    NP_001364061.1
    NP_004027.2
    XP_006711988.1
    XP_011530791.1
    XP_011530792.1
    XP_011530793.1
    XP_011530794.1
    XP_011530795.1
    XP_011530796.1
    XP_016858676.1
    XP_016858677.1
    XP_016858678.1
    XP_016858680.1
    XP_047298961.1
    XP_047298962.1
    XP_047298963.1
    XP_047298964.1
    XP_047298965.1
    XP_047298966.1
    XP_047298967.1
    XP_047298968.1
    XP_047298969.1
    XP_047298970.1
    XP_047298971.1
    XP_047298972.1
    XP_054196202.1
    XP_054196203.1
    XP_054196204.1
    XP_054196205.1
    XP_054196206.1
    XP_054196207.1
    XP_054196208.1
    XP_054196209.1
    XP_054196210.1
    XP_054196211.1
    XP_054196212.1
    XP_054196213.1
    XP_054196214.1
    XP_054196215.1
    XP_054196216.1
    XP_054196217.1
    XP_054196218.1
    XP_054196219.1
    XP_054196220.1
    XP_054196221.1
    XP_054196222.1
    XP_054196223.1
    XP_054196224.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320613.2 → NP_001307542.1  adenylate cyclase type 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC012073, BC020148, BC126235, BC144119, BM148122, HY136273
      Consensus CDS
      CCDS82424.1
      UniProtKB/TrEMBL
      A0A0A0MSC1, B7ZLX9
      Related
      ENSP00000384484.2, ENST00000405392.6
      Conserved Domains (3) summary
      smart00044
      Location:884 → 1102
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:915 → 1122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001377128.1 → NP_001364057.1  adenylate cyclase type 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC012073
      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (2) summary
      pfam00211
      Location:936 → 1143
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. NM_001377129.1 → NP_001364058.1  adenylate cyclase type 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012073
      UniProtKB/TrEMBL
      B3KNM3
      Conserved Domains (2) summary
      pfam00211
      Location:868 → 1075
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    4. NM_001377130.1 → NP_001364059.1  adenylate cyclase type 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012073
      UniProtKB/TrEMBL
      B3KNM3
      Conserved Domains (3) summary
      pfam00211
      Location:310 → 494
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:757 → 900
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    5. NM_001377131.1 → NP_001364060.1  adenylate cyclase type 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012073
      UniProtKB/TrEMBL
      U3KQ91
      Related
      ENSP00000475652.1, ENST00000606682.5
      Conserved Domains (2) summary
      pfam00211
      Location:673 → 880
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:2 → 62
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    6. NM_001377132.1 → NP_001364061.1  adenylate cyclase type 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC012073
      Consensus CDS
      CCDS1715.1
      UniProtKB/Swiss-Prot
      B3KT86, O60266, Q53T54, Q9UDB1
      UniProtKB/TrEMBL
      B7ZLX9
      Related
      ENSP00000260600.5, ENST00000260600.9
      Conserved Domains (2) summary
      pfam00211
      Location:914 → 1121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    7. NM_004036.5 → NP_004027.2  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_004027.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC012073, BC020148, BC126235, BM148122, HY136273
      Consensus CDS
      CCDS1715.1
      UniProtKB/Swiss-Prot
      B3KT86, O60266, Q53T54, Q9UDB1
      UniProtKB/TrEMBL
      B7ZLX9
      Related
      ENSP00000505261.1, ENST00000679454.1
      Conserved Domains (2) summary
      pfam00211
      Location:914 → 1121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24819169..24920237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443014.1 → XP_047298970.1  adenylate cyclase type 3 isoform X20

      UniProtKB/TrEMBL
      B3KNM3

    2. XM_047443012.1 → XP_047298968.1  adenylate cyclase type 3 isoform X18

      UniProtKB/TrEMBL
      B3KNM3

    3. XM_047443009.1 → XP_047298965.1  adenylate cyclase type 3 isoform X15

      UniProtKB/TrEMBL
      B7ZLX9

    4. XM_047443010.1 → XP_047298966.1  adenylate cyclase type 3 isoform X16

      UniProtKB/TrEMBL
      B7ZLX9

    5. XM_047443008.1 → XP_047298964.1  adenylate cyclase type 3 isoform X14

      UniProtKB/TrEMBL
      B3KNM3

    6. XM_017003187.2 → XP_016858676.1  adenylate cyclase type 3 isoform X5

      UniProtKB/TrEMBL
      B7ZLX9

    7. XM_011532491.2 → XP_011530793.1  adenylate cyclase type 3 isoform X4

      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (3) summary
      smart00044
      Location:903 → 1121
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:934 → 1141
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    8. XM_011532494.2 → XP_011530796.1  adenylate cyclase type 3 isoform X13

      UniProtKB/TrEMBL
      B3KNM3
      Conserved Domains (3) summary
      smart00044
      Location:859 → 1077
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:890 → 1097
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    9. XM_047443013.1 → XP_047298969.1  adenylate cyclase type 3 isoform X19

      UniProtKB/TrEMBL
      B3KNM3

    10. XM_047443007.1 → XP_047298963.1  adenylate cyclase type 3 isoform X12

      UniProtKB/TrEMBL
      B7ZLX9

    11. XM_006711925.2 → XP_006711988.1  adenylate cyclase type 3 isoform X3

      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (3) summary
      smart00044
      Location:906 → 1124
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:937 → 1144
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    12. XM_047443006.1 → XP_047298962.1  adenylate cyclase type 3 isoform X11

      UniProtKB/TrEMBL
      B7ZLX9

    13. XM_017003189.2 → XP_016858678.1  adenylate cyclase type 3 isoform X10

      UniProtKB/TrEMBL
      B3KNM3

    14. XM_047443011.1 → XP_047298967.1  adenylate cyclase type 3 isoform X17

      UniProtKB/TrEMBL
      B3KNM3

    15. XM_011532493.2 → XP_011530795.1  adenylate cyclase type 3 isoform X9

      UniProtKB/TrEMBL
      B3KNM3
      Conserved Domains (3) summary
      smart00044
      Location:879 → 1097
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:910 → 1117
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    16. XM_011532490.2 → XP_011530792.1  adenylate cyclase type 3 isoform X2

      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (3) summary
      smart00044
      Location:924 → 1142
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:955 → 1162
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    17. XM_017003188.2 → XP_016858677.1  adenylate cyclase type 3 isoform X7

      UniProtKB/TrEMBL
      B7ZLX9

    18. XM_011532489.2 → XP_011530791.1  adenylate cyclase type 3 isoform X1

      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (3) summary
      smart00044
      Location:925 → 1143
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:956 → 1163
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    19. XM_011532492.3 → XP_011530794.1  adenylate cyclase type 3 isoform X6

      UniProtKB/TrEMBL
      B7ZLX9
      Conserved Domains (3) summary
      smart00044
      Location:925 → 1126
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:310 → 516
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44 → 303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    20. XM_047443005.1 → XP_047298961.1  adenylate cyclase type 3 isoform X8

      UniProtKB/TrEMBL
      B7ZLX9

    21. XM_047443016.1 → XP_047298972.1  adenylate cyclase type 3 isoform X23

      UniProtKB/TrEMBL
      U3KQ91

    22. XM_017003191.1 → XP_016858680.1  adenylate cyclase type 3 isoform X21

      UniProtKB/TrEMBL
      U3KQ91

    23. XM_047443015.1 → XP_047298971.1  adenylate cyclase type 3 isoform X22

      UniProtKB/TrEMBL
      U3KQ91

    RNA

    1. XR_007068865.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24853918..24954979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340246.1 → XP_054196221.1  adenylate cyclase type 3 isoform X20

      UniProtKB/TrEMBL
      B3KNM3

    2. XM_054340244.1 → XP_054196219.1  adenylate cyclase type 3 isoform X18

      UniProtKB/TrEMBL
      B3KNM3

    3. XM_054340241.1 → XP_054196216.1  adenylate cyclase type 3 isoform X15

      UniProtKB/TrEMBL
      B7ZLX9

    4. XM_054340242.1 → XP_054196217.1  adenylate cyclase type 3 isoform X16

      UniProtKB/TrEMBL
      B7ZLX9

    5. XM_054340240.1 → XP_054196215.1  adenylate cyclase type 3 isoform X14

      UniProtKB/TrEMBL
      B3KNM3

    6. XM_054340231.1 → XP_054196206.1  adenylate cyclase type 3 isoform X5

      UniProtKB/TrEMBL
      B7ZLX9

    7. XM_054340230.1 → XP_054196205.1  adenylate cyclase type 3 isoform X4

      UniProtKB/TrEMBL
      B7ZLX9

    8. XM_054340239.1 → XP_054196214.1  adenylate cyclase type 3 isoform X13

      UniProtKB/TrEMBL
      B3KNM3

    9. XM_054340245.1 → XP_054196220.1  adenylate cyclase type 3 isoform X19

      UniProtKB/TrEMBL
      B3KNM3

    10. XM_054340238.1 → XP_054196213.1  adenylate cyclase type 3 isoform X12

      UniProtKB/TrEMBL
      B7ZLX9

    11. XM_054340229.1 → XP_054196204.1  adenylate cyclase type 3 isoform X3

      UniProtKB/TrEMBL
      B7ZLX9

    12. XM_054340237.1 → XP_054196212.1  adenylate cyclase type 3 isoform X11

      UniProtKB/TrEMBL
      B7ZLX9

    13. XM_054340236.1 → XP_054196211.1  adenylate cyclase type 3 isoform X10

      UniProtKB/TrEMBL
      B3KNM3

    14. XM_054340243.1 → XP_054196218.1  adenylate cyclase type 3 isoform X17

      UniProtKB/TrEMBL
      B3KNM3

    15. XM_054340235.1 → XP_054196210.1  adenylate cyclase type 3 isoform X9

      UniProtKB/TrEMBL
      B3KNM3

    16. XM_054340228.1 → XP_054196203.1  adenylate cyclase type 3 isoform X2

      UniProtKB/TrEMBL
      B7ZLX9

    17. XM_054340233.1 → XP_054196208.1  adenylate cyclase type 3 isoform X7

      UniProtKB/TrEMBL
      B7ZLX9

    18. XM_054340227.1 → XP_054196202.1  adenylate cyclase type 3 isoform X1

      UniProtKB/TrEMBL
      B7ZLX9

    19. XM_054340232.1 → XP_054196207.1  adenylate cyclase type 3 isoform X6

      UniProtKB/TrEMBL
      B7ZLX9

    20. XM_054340234.1 → XP_054196209.1  adenylate cyclase type 3 isoform X8

      UniProtKB/TrEMBL
      B7ZLX9

    21. XM_054340249.1 → XP_054196224.1  adenylate cyclase type 3 isoform X23

      UniProtKB/TrEMBL
      U3KQ91

    22. XM_054340247.1 → XP_054196222.1  adenylate cyclase type 3 isoform X21

      UniProtKB/TrEMBL
      U3KQ91

    23. XM_054340248.1 → XP_054196223.1  adenylate cyclase type 3 isoform X22

      UniProtKB/TrEMBL
      U3KQ91

    RNA

    1. XR_008486253.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60266.3 GenPept UniProtKB/Swiss-Prot:O60266

    Gene LinkOut

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