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    PSG3 pregnancy specific beta-1-glycoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 5671, updated on 10-Dec-2024

    Summary

    Official Symbol
    PSG3provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:9520
    See related
    Ensembl:ENSG00000221826 MIM:176392; AllianceGenome:HGNC:9520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 164.7) See more
    Orthologs
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    Genomic context

    See PSG3 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42721642..42740481, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45540609..45559440, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43225794..43244633, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule pseudogene 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:43179943-43180536 Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43245994-43246209 Neighboring gene pregnancy specific beta-1-glycoprotein 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278258-43278758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278759-43279259 Neighboring gene CEA cell adhesion molecule pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 3
    Names
    PS-beta-G-3
    PSBG-3
    carcinoembryonic antigen SG5
    pregnancy-specific glycoprotein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021016.4NP_066296.2  pregnancy-specific beta-1-glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_066296.2

      Status: VALIDATED

      Source sequence(s)
      BG620196, DA833589, M93061
      Consensus CDS
      CCDS12611.1
      UniProtKB/Swiss-Prot
      Q08265, Q16557, Q9BRW2, Q9UPL4, Q9UQ77
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000332215.5, ENST00000327495.10
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42721642..42740481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527127.3XP_011525429.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

      Conserved Domains (3) summary
      cd05774
      Location:58160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:100143
      IG_like; Immunoglobulin like
      cl11960
      Location:170258
      Ig; Immunoglobulin domain
    2. XM_011527126.3XP_011525428.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

      UniProtKB/TrEMBL
      Q9UPK9
      Conserved Domains (4) summary
      cd05774
      Location:58160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:268342
      IG_like; Immunoglobulin like
      pfam13895
      Location:264342
      Ig_2; Immunoglobulin domain
      cl11960
      Location:170258
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45540609..45559440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321488.1XP_054177463.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

    2. XM_054321487.1XP_054177462.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

      UniProtKB/TrEMBL
      Q9UPK9
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