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    ZNF692 zinc finger protein 692 [ Homo sapiens (human) ]

    Gene ID: 55657, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF692provided by HGNC
    Official Full Name
    zinc finger protein 692provided by HGNC
    Primary source
    HGNC:HGNC:26049
    See related
    Ensembl:ENSG00000171163 MIM:617758; AllianceGenome:HGNC:26049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AREBP; Zfp692
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 9.4), prostate (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF692 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248850008..248859085, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248288491..248297596, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249144207..249153284, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249120460-249121010 Neighboring gene microRNA 3124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132357-249132858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132859-249133358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2881 Neighboring gene zinc finger protein 672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2886 Neighboring gene ZNF692 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249166437-249167278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249167279-249168120 Neighboring gene tRNA-Leu (anticodon CAA) 4-1 Neighboring gene piggyBac transposable element derived 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway. Chen H, et al. Eur J Med Res, 2024 Jan 30. PMID 38291502, Free PMC Article
    2. Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma. Cai H, et al. Aging (Albany NY), 2023 Nov 17. PMID 37980166, Free PMC Article
    3. ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway. Xing Y, et al. Int J Oncol, 2019 May. PMID 30816443, Free PMC Article
    4. A clinical, biologic and mechanistic analysis of the role of ZNF692 in cervical cancer. Zhu B, et al. Gynecol Oncol, 2019 Feb. PMID 30466806
    5. ZNF692 promotes proliferation and cell mobility in lung adenocarcinoma. Zhang Q, et al. Biochem Biophys Res Commun, 2017 Sep 2. PMID 28669730

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
      Title: ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
    2. ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.
      Title: ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.
    3. ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway.
      Title: ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway.
    4. Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma.
      Title: Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma.
    5. Results found that ZNF692 was upregulated in colon adenocarcinoma (COAD) tissues and cells and that high ZNF692 expression was significantly correlated with lymph node metastasis, distant metastasis and tumor stage in COAD patients. Furthermore, ZNF692 promoted COAD cell proliferation, migration and invasion via the PI3K/AKT pathway, suggesting that ZNF692 may serve as a novel oncogene for COAD.
      Title: ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway.
    6. ZNF692 promotes CC cells proliferation and invasion through suppressing p27(kip1) transcription by directly binding its promoter region.
      Title: A clinical, biologic and mechanistic analysis of the role of ZNF692 in cervical cancer.
    7. The results show that ZNF692 is expressed in LUAD tissues compared to adjacent normal tissues, and hyper-expression of ZNF692 in LUAD is an independent risk factor for worse overall survival in LUAD patients (HR: 8.800, 95%CI: 1.082-71.560, P = 0.042) by Tissue Microarray stain assay (TMA).
      Title: ZNF692 promotes proliferation and cell mobility in lung adenocarcinoma.
    8. cloning and characterization of a novel zinc finger transcription factor referred to as AREBP. AREBP is phosphorylated at Ser(470) by AMPK.
      Title: AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20531

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 692
    Names
    AICAR responsive element binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136036.3 → NP_001129508.1  zinc finger protein 692 isoform 1

      See identical proteins and their annotated locations for NP_001129508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK302187, AL672291, DA147512, DB520788, H07076
      Consensus CDS
      CCDS44348.1
      UniProtKB/Swiss-Prot
      Q9BU19
      Related
      ENSP00000391200.1, ENST00000451251.5
      Conserved Domains (4) summary
      COG5048
      Location:389 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394 → 416
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:408 → 433
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001193328.2 → NP_001180257.1  zinc finger protein 692 isoform 3

      See identical proteins and their annotated locations for NP_001180257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different first exon, which results in the use of a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK225535, AK302187, H07076
      Consensus CDS
      CCDS53487.1
      UniProtKB/Swiss-Prot
      Q9BU19
      Related
      ENSP00000355427.3, ENST00000366471.7
      Conserved Domains (3) summary
      sd00017
      Location:316 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344 → 366
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:358 → 383
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001350072.2 → NP_001337001.1  zinc finger protein 692 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different first exon, which results in the use of a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus and lacks an internal aa when it is compared to isoform 1.
      Source sequence(s)
      BC002948, DA319079
      Conserved Domains (4) summary
      COG5189
      Location:289 → 407
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:357 → 484
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:360 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26386
      Location:208 → 332
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    4. NM_001350073.2 → NP_001337002.1  zinc finger protein 692 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a different first exon, and uses alternate splice sites at another exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL672291, BC002948, DA319079, DA765600
      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86 → 204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154 → 281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157 → 179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4 → 121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    5. NM_017865.4 → NP_060335.2  zinc finger protein 692 isoform 2

      See identical proteins and their annotated locations for NP_060335.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different first exon, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      BC002948, DA319079
      Consensus CDS
      CCDS31127.1
      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97
      Related
      ENSP00000305483.5, ENST00000306601.9
      Conserved Domains (4) summary
      COG5189
      Location:290 → 408
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:358 → 485
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:361 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:208 → 325
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248850008..248859085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424581.1 → XP_047280537.1  zinc finger protein 692 isoform X7

    2. XM_017001698.2 → XP_016857187.1  zinc finger protein 692 isoform X4

      Conserved Domains (4) summary
      COG5189
      Location:289 → 407
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:357 → 484
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:360 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26386
      Location:208 → 332
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    3. XM_017001700.2 → XP_016857189.1  zinc finger protein 692 isoform X6

    4. XM_011544222.2 → XP_011542524.1  zinc finger protein 692 isoform X3

      See identical proteins and their annotated locations for XP_011542524.1

      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97
      Conserved Domains (4) summary
      COG5189
      Location:290 → 408
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:358 → 485
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:361 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:208 → 325
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    5. XM_011544221.3 → XP_011542523.2  zinc finger protein 692 isoform X2

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (5) summary
      COG5048
      Location:179 → 280
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156 → 178
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:198 → 223
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:124 → 202
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25580
      Location:4 → 120
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    6. XM_017001699.3 → XP_016857188.2  zinc finger protein 692 isoform X5

      UniProtKB/TrEMBL
      H0YCH4
      Related
      ENSP00000431582.1, ENST00000476503.5
      Conserved Domains (3) summary
      COG5189
      Location:62 → 178
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:128 → 255
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:131 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_011544220.3 → XP_011542522.2  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86 → 204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154 → 281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157 → 179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4 → 121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    8. XM_047424596.1 → XP_047280552.1  zinc finger protein 692 isoform X10

    9. XM_017001702.3 → XP_016857191.1  zinc finger protein 692 isoform X6

    10. XM_047424586.1 → XP_047280542.1  zinc finger protein 692 isoform X9

    11. XM_047424599.1 → XP_047280555.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4

    12. XM_024448274.2 → XP_024304042.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86 → 204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154 → 281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157 → 179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4 → 121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    13. XM_011544227.2 → XP_011542529.1  zinc finger protein 692 isoform X9

      See identical proteins and their annotated locations for XP_011542529.1

      Conserved Domains (4) summary
      COG5048
      Location:357 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:362 → 384
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:376 → 401
      zf-H2C2_2; Zinc-finger double domain

    14. XM_047424603.1 → XP_047280559.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Related
      ENST00000533927.5

    15. XM_047424583.1 → XP_047280539.1  zinc finger protein 692 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      248288491..248297596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337551.1 → XP_054193526.1  zinc finger protein 692 isoform X7

    2. XM_054337548.1 → XP_054193523.1  zinc finger protein 692 isoform X4

    3. XM_054337550.1 → XP_054193525.1  zinc finger protein 692 isoform X6

    4. XM_054337547.1 → XP_054193522.1  zinc finger protein 692 isoform X3

      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97

    5. XM_054337546.1 → XP_054193521.1  zinc finger protein 692 isoform X2

      UniProtKB/TrEMBL
      H0YCH4

    6. XM_054337549.1 → XP_054193524.1  zinc finger protein 692 isoform X5

      UniProtKB/TrEMBL
      H0YCH4

    7. XM_054337545.1 → XP_054193520.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4

    8. XM_054337555.1 → XP_054193530.1  zinc finger protein 692 isoform X10

    9. XM_054337553.1 → XP_054193528.1  zinc finger protein 692 isoform X6

    10. XM_054337557.1 → XP_054193532.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4

    11. XM_054337556.1 → XP_054193531.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4

    12. XM_054337554.1 → XP_054193529.1  zinc finger protein 692 isoform X9

    13. XM_054337558.1 → XP_054193533.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4

    14. XM_054337552.1 → XP_054193527.1  zinc finger protein 692 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BU19.1 GenPept UniProtKB/Swiss-Prot:Q9BU19

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