GRWD1 glutamate rich WD repeat containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRWD1provided by HGNC
Official Full Name: glutamate rich WD repeat containing 1provided by HGNC
Primary source: HGNC:HGNC:21270
See related: Ensembl:ENSG00000105447 MIM:610597; AllianceGenome:HGNC:21270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDW4; GRWD; RRB1; WDR28
Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Expression: Ubiquitous expression in placenta (RPKM 6.8), appendix (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (48445983..48457022)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (51440151..51451183)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (48949240..48960279)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.
Title: GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.
Comprehensive Analysis of Glutamate-Rich WD Repeat-Containing Protein 1 and Its Potential Clinical Significance for Pancancer.
Title: Comprehensive Analysis of Glutamate-Rich WD Repeat-Containing Protein 1 and Its Potential Clinical Significance for Pancancer.
GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
Title: GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
findings suggest a novel oncogenic function of GRWD1 as a transcriptional regulator of p53 and that GRWD1 might be an attractive therapeutic target and prognostic marker in cancer therapy
Title: GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity.
GRWD1 overexpression in combination with HPV16 E7 and activated KRAS confers anchorage-independent growth and tumorigenic capacity on normal human fibroblasts. Consistent with this, GRWD1 overexpression is associated with poor prognosis in cancer patients.
Title: GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
Cdt1-binding protein GRWD1 promotes chromatin fluidity by influencing nucleosome structures, e.g., by transient eviction of H2A-H2B, and thereby promotes efficient MCM loading at replication origins.
Title: Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92449 (e-PCR)
- UniSTS:91435

RH12000 (e-PCR)
- UniSTS:35431

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate-rich WD repeat-containing protein 1

Names: CUL4- and DDB1-associated WDR protein 4; WD repeat domain 28; glutamate rich WD repeat protein GRWD; regulator of ribosome biogenesis 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046925.1 RefSeqGene

Range

5001..13135

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_031485.4 → NP_113673.3 glutamate-rich WD repeat-containing protein 1

Status: REVIEWED

Source sequence(s)

AC008403, BC002440, DA714522

Consensus CDS

CCDS12720.1

UniProtKB/Swiss-Prot

A0MNN5, Q8TF59, Q9BQ67

UniProtKB/TrEMBL

B2RDP6, Q8TCJ8

Related

ENSP00000253237.4, ENST00000253237.10

Conserved Domains (4) summary

COG2319
Location:197 → 383

WD40; WD40 repeat [General function prediction only]

pfam12265
Location:44 → 111

CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex

sd00039
Location:218 → 259

7WD40; WD40 repeat [structural motif]

cl02567
Location:204 → 384

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...