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    GPR161 G protein-coupled receptor 161 [ Homo sapiens (human) ]

    Gene ID: 23432, updated on 9-Dec-2024

    Summary

    Official Symbol
    GPR161provided by HGNC
    Official Full Name
    G protein-coupled receptor 161provided by HGNC
    Primary source
    HGNC:HGNC:23694
    See related
    Ensembl:ENSG00000143147 MIM:612250; AllianceGenome:HGNC:23694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RE2
    Summary
    The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR161 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168079542..168137667, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167431007..167489154, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168048780..168106905, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene microRNA 1255b-2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168025104-168025604 Neighboring gene Sharpr-MPRA regulatory region 7850 Neighboring gene GCSH pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168054775-168055275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168065654-168066154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168066155-168066655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1542 Neighboring gene Sharpr-MPRA regulatory region 11959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168147823-168148324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168163898-168164682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168166417-168166917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168177413-168178005 Neighboring gene TOR signaling pathway regulator Neighboring gene ribosomal protein L34 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ33952

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary membrane TAS
    Traceable Author Statement
    more info
     
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in glial cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 161
    Names
    G-protein coupled receptor RE2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053052.1 RefSeqGene

      Range
      5738..63126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267609.1NP_001254538.1  G-protein coupled receptor 161 isoform 1

      See identical proteins and their annotated locations for NP_001254538.1

      Status: REVIEWED

      Source sequence(s)
      AA662800, AK299634, AL033532
      Consensus CDS
      CCDS58043.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000441039.1, ENST00000537209.5
      Conserved Domains (2) summary
      pfam00001
      Location:64344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:55184
      7tm_4; Olfactory receptor
    2. NM_001267610.2NP_001254539.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_001254539.1

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Related
      ENSP00000356809.1, ENST00000367835.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001267611.1NP_001254540.1  G-protein coupled receptor 161 isoform 3

      See identical proteins and their annotated locations for NP_001254540.1

      Status: REVIEWED

      Source sequence(s)
      AA662800, AK310019, AL033532
      Consensus CDS
      CCDS72978.1
      UniProtKB/TrEMBL
      A0A0A0MQW8
      Related
      ENSP00000271357.6, ENST00000271357.9
      Conserved Domains (2) summary
      pfam00001
      Location:61341
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52181
      7tm_4; Olfactory receptor
    4. NM_001267612.2NP_001254541.1  G-protein coupled receptor 161 isoform 4

      See identical proteins and their annotated locations for NP_001254541.1

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS58042.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000356810.1, ENST00000367836.5
      Conserved Domains (2) summary
      cd14964
      Location:1032
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. NM_001267613.1NP_001254542.1  G-protein coupled receptor 161 isoform 5

      See identical proteins and their annotated locations for NP_001254542.1

      Status: REVIEWED

      Source sequence(s)
      AA662800, AK298797, AL033532
      Consensus CDS
      CCDS58044.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000437576.1, ENST00000539777.5
      Conserved Domains (2) summary
      cd14964
      Location:6884
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:48257
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    6. NM_001267614.1NP_001254543.1  G-protein coupled receptor 161 isoform 6

      See identical proteins and their annotated locations for NP_001254543.1

      Status: REVIEWED

      Source sequence(s)
      AA662800, AK298850, AL033532
      Consensus CDS
      CCDS58045.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000444348.1, ENST00000546300.5
      Conserved Domains (1) summary
      pfam00001
      Location:12210
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. NM_001349632.1NP_001336561.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001349633.1NP_001336562.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001349634.1NP_001336563.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. NM_001349635.1NP_001336564.1  G-protein coupled receptor 161 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS58042.1
      Conserved Domains (2) summary
      cd14964
      Location:1032
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    11. NM_001375883.1NP_001362812.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Related
      ENSP00000506967.1, ENST00000682931.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    12. NM_001375884.1NP_001362813.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    13. NM_001375885.1NP_001362814.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    14. NM_001381909.1NP_001368838.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    15. NM_153832.3NP_722561.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_722561.1

      Status: REVIEWED

      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      B3KV34, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2, Q8N6U8
      Related
      ENSP00000356812.1, ENST00000367838.5
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      168079542..168137667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      167431007..167489154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007369.2: Suppressed sequence

      Description
      NM_007369.2: This RefSeq was suppressed because it mistakenly represents a partial CDS. The full-length CDS is represented in a different record (NM_153832).