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    PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A [ Homo sapiens (human) ]

    Gene ID: 5494, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPM1Aprovided by HGNC
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:9275
    See related
    Ensembl:ENSG00000100614 MIM:606108; AllianceGenome:HGNC:9275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP2CA; PP2Calpha; PP2C-ALPHA
    Summary
    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPM1A in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60245750..60299087)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54452043..54505381)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60712468..60765805)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8472 Neighboring gene ribosomal protein L17 pseudogene 2 Neighboring gene uncharacterized LOC101927702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8473 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:60715285-60716013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5810 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60748999-60750198 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:60782171-60783050 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:60783051-60783930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:60785365-60785909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5811 Neighboring gene long intergenic non-protein coding RNA 2322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8478 Neighboring gene GNRHR2 pseudogene 1 Neighboring gene RBM8A pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis. Schaaf K, et al. Sci Rep, 2017 Feb 8. PMID 28176854, Free PMC Article
    2. Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients. Flannery PC, et al. Eur J Drug Metab Pharmacokinet, 2020 Apr. PMID 31792727
    3. Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Regulates Host Gene PPM1A Related to Hepatocellular Carcinoma. Chavalit T, et al. Microrna, 2020. PMID 31686644
    4. Kinetic analysis of human serine/threonine protein phosphatase 2Calpha. Fjeld CC, et al. J Biol Chem, 1999 Jul 16. PMID 10400656
    5. A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity. Debnath S, et al. J Biol Chem, 2018 May 25. PMID 29602904, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis and the intervention effect of tanshinone IIA.
      Title: Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis and the intervention effect of tanshinone IIA.
    2. Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway.
      Title: Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway.
    3. Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage.
      Title: Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage.
    4. Knockdown of TRIM65 suppressed the proliferation and invasiveness of gastric cancer cells by restricting the ubiquitin degradation of PPM1A.
      Title: Knockdown of TRIM65 suppressed the proliferation and invasiveness of gastric cancer cells by restricting the ubiquitin degradation of PPM1A.
    5. A comprehensive overview of PPM1A: From structure to disease.
      Title: A comprehensive overview of PPM1A: From structure to disease.
    6. lncRNA TSPEAR-AS2, a Novel Prognostic Biomarker, Promotes Oral Squamous Cell Carcinoma Progression by Upregulating PPM1A via Sponging miR-487a-3p.
      Title: lncRNA TSPEAR-AS2, a Novel Prognostic Biomarker, Promotes Oral Squamous Cell Carcinoma Progression by Upregulating PPM1A via Sponging miR-487a-3p.
    7. Role of active site arginine residues in substrate recognition by PPM1A.
      Title: Role of active site arginine residues in substrate recognition by PPM1A.
    8. MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A.
      Title: MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A.
    9. PPM1A suppresses the proliferation and invasiveness of RCC cells via Smad2/3 signaling inhibition.
      Title: PPM1A suppresses the proliferation and invasiveness of RCC cells via Smad2/3 signaling inhibition.
    10. Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Regulates Host Gene PPM1A Related to Hepatocellular Carcinoma.
      Title: Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Regulates Host Gene PPM1A Related to Hepatocellular Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) by siRNA ehnahces HIV-1 gene expression in resting CD4+ T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9201, FLJ42306

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein myristoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1A
    NP_066283.1
    NP_808820.1
    NP_808821.2
    XP_011535183.1
    XP_011535185.1
    XP_016876872.1
    XP_024305405.1
    XP_047287455.1
    XP_047287456.1
    XP_047287457.1
    XP_047287458.1
    XP_047287459.1
    XP_047287460.1
    XP_047287461.1
    XP_047287462.1
    XP_047287463.1
    XP_047287464.1
    XP_047287465.1
    XP_047287466.1
    XP_047287467.1
    XP_047287468.1
    XP_047287469.1
    XP_047287470.1
    XP_047287471.1
    XP_047287472.1
    XP_054232229.1
    XP_054232230.1
    XP_054232231.1
    XP_054232232.1
    XP_054232233.1
    XP_054232234.1
    XP_054232235.1
    XP_054232236.1
    XP_054232237.1
    XP_054232238.1
    XP_054232239.1
    XP_054232240.1
    XP_054232241.1
    XP_054232242.1
    XP_054232243.1
    XP_054232244.1
    XP_054232245.1
    XP_054232246.1
    XP_054232247.1
    XP_054232248.1
    XP_054232249.1
    XP_054232250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029698.1 RefSeqGene

      Range
      8470..58336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021003.5 → NP_066283.1  protein phosphatase 1A isoform 1

      See identical proteins and their annotated locations for NP_066283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI076736, AL132778, AL157756, BC063243, DA439296
      Consensus CDS
      CCDS9744.1
      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Related
      ENSP00000378514.4, ENST00000395076.9
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 363
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    2. NM_177951.3 → NP_808820.1  protein phosphatase 1A isoform 2

      See identical proteins and their annotated locations for NP_808820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon within the 5' UTR and lacks a few of 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF070670, AL157756, CB156710, DA439296
      Consensus CDS
      CCDS9745.1
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Related
      ENSP00000314850.3, ENST00000325658.3
      Conserved Domains (2) summary
      pfam00481
      Location:22 → 284
      PP2C; Protein phosphatase 2C
      cl29762
      Location:285 → 317
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    3. NM_177952.3 → NP_808821.2  protein phosphatase 1A isoform 3

      See identical proteins and their annotated locations for NP_808821.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. It encodes isoform 3, which has a distinct and longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AI076736, AK097843, AK313337, AL132778, AL157756, BC063243
      Consensus CDS
      CCDS45120.1
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Related
      ENSP00000327255.3, ENST00000325642.7
      Conserved Domains (2) summary
      pfam00481
      Location:95 → 357
      PP2C; Protein phosphatase 2C
      pfam07830
      Location:358 → 433
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      60245750..60299087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431505.1 → XP_047287461.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    2. XM_047431508.1 → XP_047287464.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    3. XM_047431511.1 → XP_047287467.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    4. XM_047431512.1 → XP_047287468.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    5. XM_047431516.1 → XP_047287472.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    6. XM_047431499.1 → XP_047287455.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    7. XM_047431501.1 → XP_047287457.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    8. XM_017021383.2 → XP_016876872.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    9. XM_047431507.1 → XP_047287463.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    10. XM_047431513.1 → XP_047287469.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    11. XM_047431515.1 → XP_047287471.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    12. XM_024449637.2 → XP_024305405.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 363
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    13. XM_047431500.1 → XP_047287456.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    14. XM_047431510.1 → XP_047287466.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    15. XM_047431506.1 → XP_047287462.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    16. XM_047431514.1 → XP_047287470.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    17. XM_011536883.2 → XP_011535185.1  protein phosphatase 1A isoform X3

      See identical proteins and their annotated locations for XP_011535185.1

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 363
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    18. XM_047431509.1 → XP_047287465.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    19. XM_047431503.1 → XP_047287459.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    20. XM_047431504.1 → XP_047287460.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    21. XM_011536881.4 → XP_011535183.1  protein phosphatase 1A isoform X3

      See identical proteins and their annotated locations for XP_011535183.1

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 363
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    22. XM_047431502.1 → XP_047287458.1  protein phosphatase 1A isoform X2

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      54452043..54505381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376262.1 → XP_054232237.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    2. XM_054376265.1 → XP_054232240.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    3. XM_054376268.1 → XP_054232243.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    4. XM_054376269.1 → XP_054232244.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    5. XM_054376275.1 → XP_054232250.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    6. XM_054376254.1 → XP_054232229.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    7. XM_054376256.1 → XP_054232231.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    8. XM_054376257.1 → XP_054232232.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    9. XM_054376264.1 → XP_054232239.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    10. XM_054376270.1 → XP_054232245.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    11. XM_054376272.1 → XP_054232247.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    12. XM_054376274.1 → XP_054232249.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    13. XM_054376255.1 → XP_054232230.1  protein phosphatase 1A isoform X1

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    14. XM_054376267.1 → XP_054232242.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    15. XM_054376263.1 → XP_054232238.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    16. XM_054376271.1 → XP_054232246.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    17. XM_054376273.1 → XP_054232248.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    18. XM_054376266.1 → XP_054232241.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    19. XM_054376259.1 → XP_054232234.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    20. XM_054376260.1 → XP_054232235.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    21. XM_054376261.1 → XP_054232236.1  protein phosphatase 1A isoform X3

      UniProtKB/Swiss-Prot
      B5BU11, J3KNM0, O75551, P35813
      UniProtKB/TrEMBL
      B2R8E4, B5BUD5

    22. XM_054376258.1 → XP_054232233.1  protein phosphatase 1A isoform X2

      UniProtKB/TrEMBL
      B2R8E4, B5BUD5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35813.1 GenPept UniProtKB/Swiss-Prot:P35813

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