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    PCBP2 poly(rC) binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 5094, updated on 10-Dec-2024

    Summary

    Official Symbol
    PCBP2provided by HGNC
    Official Full Name
    poly(rC) binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:8648
    See related
    Ensembl:ENSG00000197111 MIM:601210; AllianceGenome:HGNC:8648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPE2; HNRNPE2; hnRNP-E2
    Summary
    The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
    Expression
    Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PCBP2 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53452102..53481162)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53418139..53447209)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53845886..53874946)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53834490-53835255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4510 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4513 Neighboring gene proline rich 13 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53876139-53876652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4514 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene Sharpr-MPRA regulatory region 1043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene ATF7-NPFF readthrough Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E2 PubMed
    Tat tat Poly(rC) binding protein 2 (PCBP2) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC110998

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding PubMed 
    enables enzyme binding PubMed 
    enables lncRNA binding PubMed 
    enables mRNA binding  
    enables promoter-enhancer loop anchoring activity PubMed 
    enables protein binding PubMed 
    enables protein binding PubMed 
    enables single-stranded DNA binding  
    enables ubiquitin protein ligase binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in focal adhesion PubMed 
    located_in membrane PubMed 
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in postsynaptic density  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    poly(rC)-binding protein 2
    Names
    alpha-CP2
    epididymis secretory sperm binding protein
    heterogeneous nuclear ribonucleoprotein E2
    heterogenous nuclear ribonucleoprotein E2
    hnRNP E2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098620.3 → NP_001092090.1  poly(rC)-binding protein 2 isoform c

      See identical proteins and their annotated locations for NP_001092090.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BF509278
      Consensus CDS
      CCDS44903.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000352228.5, ENST00000359282.9
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    2. NM_001128911.2 → NP_001122383.1  poly(rC)-binding protein 2 isoform d

      See identical proteins and their annotated locations for NP_001122383.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is one amino acid shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BF509278, X78136
      Consensus CDS
      CCDS44901.1
      UniProtKB/Swiss-Prot
      A8K7X6, B4DXP5, F8VYL7, G3V0E8, I6L8F9, Q15366, Q32Q82, Q59HD4, Q68Y55, Q6IPF4, Q6PKG5
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000408949.2, ENST00000439930.7
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:284 → 359
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    3. NM_001128912.2 → NP_001122384.1  poly(rC)-binding protein 2 isoform e

      See identical proteins and their annotated locations for NP_001122384.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses two alternate in-frame splice sites compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is five amino acids shorter compared to isoform a.
      Source sequence(s)
      AB188306, AB208825, AC023509, AK130583, BF509278
      Consensus CDS
      CCDS55830.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000448927.2, ENST00000552296.6
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:280 → 355
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    4. NM_001128913.2 → NP_001122385.1  poly(rC)-binding protein 2 isoform f

      See identical proteins and their annotated locations for NP_001122385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, BC107688, BF509278
      Consensus CDS
      CCDS44902.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000394116.1, ENST00000447282.5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:254 → 329
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    5. NM_001128914.2 → NP_001122386.1  poly(rC)-binding protein 2 isoform g

      See identical proteins and their annotated locations for NP_001122386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, AK225357, BF509278
      Consensus CDS
      CCDS44904.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000390304.1, ENST00000437231.5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:237 → 312
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    6. NM_005016.6 → NP_005007.2  poly(rC)-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_005007.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB188306, AC023509, AK130583, BC035420, BF509278
      Consensus CDS
      CCDS44900.1
      UniProtKB/TrEMBL
      A0A384N6B9, H3BRU6
      Related
      ENSP00000352438.5, ENST00000359462.9
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:285 → 360
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    7. NM_031989.5 → NP_114366.1  poly(rC)-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_114366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB188306, AC023509, AK130583, AK292141, BF509278
      Consensus CDS
      CCDS8859.1
      UniProtKB/TrEMBL
      H3BRU6
      Related
      ENSP00000448762.2, ENST00000546463.6
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53452102..53481162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53418139..53447209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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