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    Tspan2 tetraspanin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tspan2provided by RGD
    Official Full Name
    tetraspanin 2provided by RGD
    Primary source
    RGD:620982
    See related
    EnsemblRapid:ENSRNOG00000082472 AllianceGenome:RGD:620982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tspan-2
    Summary
    Predicted to act upstream of or within inflammatory response and nervous system development. Predicted to be located in myelin sheath and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 362.4), Brain (RPKM 341.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (192866212..192923489)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (190177717..190234994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205160405..205202766)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nerve growth factor Neighboring gene uncharacterized LOC102549793 Neighboring gene uncharacterized LOC134485941 Neighboring gene uncharacterized LOC134485942 Neighboring gene thyroid stimulating hormone subunit beta Neighboring gene synaptonemal complex protein 1 Neighboring gene nuclear receptor subfamily 1, group H, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel rat tetraspan protein in cells of the oligodendrocyte lineage. Birling MC, et al. J Neurochem, 1999 Dec. PMID 10582623
    2. Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. de Monasterio-Schrader P, et al. Glia, 2013 Nov. PMID 24038504
    3. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
    4. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within astrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microglia development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-2
    Names
    tetraspan 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022589.2 → NP_072111.1  tetraspanin-2

      See identical proteins and their annotated locations for NP_072111.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JJW1
      UniProtKB/TrEMBL
      A6K3J1
      Related
      ENSRNOP00000106244.1, ENSRNOT00000168273.1
      Conserved Domains (2) summary
      cd03151
      Location:110 → 186
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 214
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      192866212..192923489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005500365.2 RNA Sequence

    2. XR_005500364.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJW1.1 GenPept UniProtKB/Swiss-Prot:Q9JJW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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