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    Sh2b2 SH2B adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114203, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh2b2provided by RGD
    Official Full Name
    SH2B adaptor protein 2provided by RGD
    Primary source
    RGD:69284
    See related
    EnsemblRapid:ENSRNOG00000001425 AllianceGenome:RGD:69284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aps
    Summary
    Enables identical protein binding activity. Involved in nervous system development and regulation of Ras protein signal transduction. Predicted to be located in actin cytoskeleton; cytosol; and ruffle. Predicted to be active in plasma membrane. Orthologous to human SH2B2 (SH2B adaptor protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 43.7), Thymus (RPKM 33.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2b2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26063812..26093468)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20427057..20456845)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23471477..23501043)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481274 Neighboring gene uncharacterized LOC134481273 Neighboring gene cut-like homeobox 1 Neighboring gene uncharacterized LOC134481275 Neighboring gene uncharacterized LOC134481276 Neighboring gene PRKR interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains. Iseki M, et al. Mol Cell Biol, 2004 Mar. PMID 14993264, Free PMC Article
    2. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Hu J, et al. Mol Cell, 2003 Dec. PMID 14690593
    3. Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Hu J, et al. J Mol Biol, 2006 Aug 4. PMID 16824542
    4. Identification of the APS protein as a novel insulin receptor substrate. Moodie SA, et al. J Biol Chem, 1999 Apr 16. PMID 10196204
    5. Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. Katsanakis KD, et al. J Biol Chem, 2005 Nov 11. PMID 16141217

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APS was identified as a novel substrate for protein kinase B/Akt.
      Title: Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within B-1 B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen receptor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH2B adapter protein 2
    Names
    SH2 and PH domain-containing adapter protein APS
    adapter protein with pleckstrin homology and Src homology 2 domains
    adaptor protein with pleckstrin homology and src homology 2 domains

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053669.2 → NP_446121.1  SH2B adapter protein 2

      See identical proteins and their annotated locations for NP_446121.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q9Z200
      UniProtKB/TrEMBL
      A0A8I6GLZ7, A6J076
      Related
      ENSRNOP00000001935.5, ENSRNOT00000001935.7
      Conserved Domains (5) summary
      cd10411
      Location:401 → 496
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:186 → 301
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 295
      PH; PH domain
      pfam08916
      Location:17 → 73
      Phe_ZIP; Phenylalanine zipper
      cl00807
      Location:149 → 172
      MNHE; Na+/H+ ion antiporter subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26063812..26093468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089010.2 → XP_038944938.1  SH2B adapter protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLZ7
      Conserved Domains (3) summary
      cd10411
      Location:434 → 529
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:220 → 335
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:51 → 107
      Phe_ZIP; Phenylalanine zipper

    2. XM_008769112.4 → XP_008767334.1  SH2B adapter protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008767334.1

      UniProtKB/TrEMBL
      A0A8I6GLZ7
      Related
      ENSRNOP00000097265.2, ENSRNOT00000102136.2
      Conserved Domains (5) summary
      cd10411
      Location:435 → 530
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:220 → 335
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:238 → 329
      PH; PH domain
      pfam08916
      Location:51 → 107
      Phe_ZIP; Phenylalanine zipper
      cl00807
      Location:183 → 206
      MNHE; Na+/H+ ion antiporter subunit

    3. XM_017598239.3 → XP_017453728.1  SH2B adapter protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q9Z200
      UniProtKB/TrEMBL
      A0A8I6GLZ7, A6J076
      Conserved Domains (5) summary
      cd10411
      Location:401 → 496
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:186 → 301
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 295
      PH; PH domain
      pfam08916
      Location:17 → 73
      Phe_ZIP; Phenylalanine zipper
      cl00807
      Location:149 → 172
      MNHE; Na+/H+ ion antiporter subunit

    4. XM_008769113.4 → XP_008767335.1  SH2B adapter protein 2 isoform X3

      See identical proteins and their annotated locations for XP_008767335.1

      UniProtKB/Swiss-Prot
      Q9Z200
      UniProtKB/TrEMBL
      A0A8I6GLZ7, A6J076
      Conserved Domains (5) summary
      cd10411
      Location:401 → 496
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:186 → 301
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 295
      PH; PH domain
      pfam08916
      Location:17 → 73
      Phe_ZIP; Phenylalanine zipper
      cl00807
      Location:149 → 172
      MNHE; Na+/H+ ion antiporter subunit

    5. XM_017598238.3 → XP_017453727.1  SH2B adapter protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q9Z200
      UniProtKB/TrEMBL
      A0A8I6GLZ7, A6J076
      Conserved Domains (5) summary
      cd10411
      Location:401 → 496
      SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:186 → 301
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 295
      PH; PH domain
      pfam08916
      Location:17 → 73
      Phe_ZIP; Phenylalanine zipper
      cl00807
      Location:149 → 172
      MNHE; Na+/H+ ion antiporter subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z200.1 GenPept UniProtKB/Swiss-Prot:Q9Z200

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