Cntf ciliary neurotrophic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntfprovided by RGD
Official Full Name: ciliary neurotrophic factorprovided by RGD
Primary source: RGD:2370
See related: EnsemblRapid:ENSRNOG00000012460 AllianceGenome:RGD:2370
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including glial cell projection; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 64.1), Muscle (RPKM 61.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (219312512..219314535, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (209887854..209889877, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (229599009..229601032, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
Title: Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
Title: Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways.
Title: Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways.
Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration.
Title: Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration.
CNTF activates Akt-Nrf2 signaling to protect myocardial cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation.
Title: Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling.
endogenous SNCA plays a crucial role in spinal neuronal survival, in which the underlying mechanism may be linked to the regulation both apoptotic genes (Caspase7/9) and CNTF.
Title: Effects of Alpha-Synuclein on Primary Spinal Cord Neurons Associated with Apoptosis and CNTF Expression.
Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
Title: Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo.
Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1.
Title: Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
FGF-2 down-regulated the expression of endogenous CNTF.
Title: Fibroblast growth factor-2 counteracts the effect of ciliary neurotrophic factor on spontaneous differentiation in adult hippocampal progenitor cells.
CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential.
Title: Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).

Submit: New GeneRIF Correction See all GeneRIFs (54)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127650 (e-PCR)
- UniSTS:210960

RH94581 (e-PCR)
- UniSTS:119829

Cntf (e-PCR), detects polymorphism
- UniSTS:506808

RH128594 (e-PCR)
- UniSTS:211902

D1Bda54 (e-PCR)
- UniSTS:239807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in astrocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in axon regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of photoreceptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein modification process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of resting membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of retinal cell programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of retinal cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal rod cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of retinal rod cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glial cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane bounded cell projection cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ciliary neurotrophic factor

Names: ciliary neurotropic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013166.2 → NP_037298.2 ciliary neurotrophic factor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P20294

UniProtKB/TrEMBL

A6I0E7, G3V7M6

Related

ENSRNOP00000016690.1, ENSRNOT00000016690.4

Conserved Domains (1) summary

pfam01110
Location:1 → 187

CNTF; Ciliary neurotrophic factor