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    Thoc6 THO complex subunit 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thoc6provided by RGD
    Official Full Name
    THO complex subunit 6provided by RGD
    Primary source
    RGD:708553
    See related
    EnsemblRapid:ENSRNOG00000003497 AllianceGenome:RGD:708553
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pdrp
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in central nervous system development and mRNA export from nucleus. Predicted to be located in chromosome, telomeric region and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC6 (THO complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 96.3), Adrenal (RPKM 71.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc6 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13204643..13210004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12700051..12705411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12989135..12994495, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene uncharacterized LOC102557038 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene host cell factor C1 regulator 1 Neighboring gene TNF receptor superfamily member 12A Neighboring gene claudin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intellectual disability associated with a homozygous missense mutation in THOC6. Beaulieu CL, et al. Orphanet J Rare Dis, 2013 Apr 26. PMID 23621916, Free PMC Article
    2. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
    3. mRNA export and the TREX complex. Katahira J. Biochim Biophys Acta, 2012 Jun. PMID 22178508
    4. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. Boyne JR, et al. PLoS Pathog, 2008 Oct. PMID 18974867, Free PMC Article
    5. Human mRNA export machinery recruited to the 5' end of mRNA. Cheng H, et al. Cell, 2006 Dec 29. PMID 17190602

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 6 homolog
    Names
    THO complex 6 homolog
    WD repeat-containing protein 58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024384.2 → NP_077360.2  THO complex subunit 6 homolog

      See identical proteins and their annotated locations for NP_077360.2

      Status: PROVISIONAL

      Source sequence(s)
      BC079149
      UniProtKB/Swiss-Prot
      Q6AY87
      UniProtKB/TrEMBL
      A0A8I5ZT92
      Related
      ENSRNOP00000004672.3, ENSRNOT00000004672.5
      Conserved Domains (2) summary
      sd00039
      Location:28 → 74
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:27 → 285
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13204643..13210004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269913.1 → XP_063125983.1  THO complex subunit 6 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT92

    2. XM_063269914.1 → XP_063125984.1  THO complex subunit 6 homolog isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY87.1 GenPept UniProtKB/Swiss-Prot:Q6AY87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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