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    Prorp protein only RNase P catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prorpprovided by RGD
    Official Full Name
    protein only RNase P catalytic subunitprovided by RGD
    Primary source
    RGD:1305089
    See related
    EnsemblRapid:ENSRNOG00000007043 AllianceGenome:RGD:1305089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrpp3; RGD1305089
    Summary
    Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Predicted to be located in mitochondrial nucleoid and nucleoplasm. Predicted to be part of mitochondrial ribonuclease P complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 99.3), Thymus (RPKM 95.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prorp in Genome Data Viewer
    Location:
    6q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78404821..78497562)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72669659..72762419)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (76079880..76171298)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene signal recognition particle 54A Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene NFKB inhibitor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the nuclease subunit of human mitochondrial RNase P. Reinhard L, et al. Nucleic Acids Res, 2015 Jun 23. PMID 25953853, Free PMC Article
    2. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Holzmann J, et al. Cell, 2008 Oct 31. PMID 18984158
    3. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA 5'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 5'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA 5'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial ribonuclease P complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribonuclease P catalytic subunit
    Names
    mitochondrial RNase P protein 3
    mitochondrial ribonuclease P protein 3
    NP_001100200.1
    XP_038967903.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106730.2 → NP_001100200.1  mitochondrial ribonuclease P catalytic subunit precursor

      See identical proteins and their annotated locations for NP_001100200.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168878
      UniProtKB/Swiss-Prot
      B5DF07
      UniProtKB/TrEMBL
      A0A8I6AEM3
      Related
      ENSRNOP00000009306.4, ENSRNOT00000009304.6
      Conserved Domains (2) summary
      sd00004
      Location:174 → 204
      PPR; PPR repeat [structural motif]
      pfam16953
      Location:342 → 578
      PRORP; Protein-only RNase P

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      78404821..78497562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111975.2 → XP_038967903.1  mitochondrial ribonuclease P catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam16953
      Location:1 → 206
      PRORP; Protein-only RNase P
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DF07.1 GenPept UniProtKB/Swiss-Prot:B5DF07

    Gene LinkOut

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