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    Igsf21 immunoglobin superfamily, member 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298591, updated on 9-Dec-2024

    Summary

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    Symbol
    Igsf21provided by RGD
    Full Name
    immunoglobin superfamily, member 21provided by RGD
    Primary source
    RGD:1310117
    See related
    EnsemblRapid:ENSRNOG00000049959 AllianceGenome:RGD:1310117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310117
    Summary
    Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; synapse maturation; and trans-synaptic signaling, modulating synaptic transmission. Predicted to be located in external side of plasma membrane and inhibitory synapse. Predicted to be active in postsynaptic density membrane and presynaptic membrane. Orthologous to human IGSF21 (immunoglobin superfamily member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 42.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igsf21 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (157570964..157795290, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (152287834..152512174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (158503090..158735702, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like Neighboring gene kelch domain containing 7A Neighboring gene uncharacterized LOC134487088 Neighboring gene uncharacterized LOC134479044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α. Tanabe Y, et al. Nat Commun, 2017 Sep 1. PMID 28864826, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in trans-synaptic signaling, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trans-synaptic signaling, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in inhibitory synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271454.2 → NP_001258383.1  immunoglobulin superfamily member 21 precursor

      See identical proteins and their annotated locations for NP_001258383.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      M0RAS4
      UniProtKB/TrEMBL
      A6ITN5
      Related
      ENSRNOP00000066631.3, ENSRNOT00000074336.4
      Conserved Domains (1) summary
      cl11960
      Location:372 → 432
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      157570964..157795290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109686.2 → XP_038965614.1  immunoglobulin superfamily member 21 isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:178 → 182
      Ig; Ig strand C [structural motif]
      cl11960
      Location:175 → 235
      Ig; Immunoglobulin domain

    2. XM_039109685.2 → XP_038965613.1  immunoglobulin superfamily member 21 isoform X1

      Related
      ENSRNOP00000107300.1, ENSRNOT00000141290.1
      Conserved Domains (2) summary
      cd00096
      Location:332 → 336
      Ig; Ig strand C [structural motif]
      cl11960
      Location:329 → 389
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M0RAS4.3 GenPept UniProtKB/Swiss-Prot:M0RAS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools