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    Klhl5 kelch-like family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl5provided by RGD
    Official Full Name
    kelch-like family member 5provided by RGD
    Primary source
    RGD:1309661
    See related
    EnsemblRapid:ENSRNOG00000008421 AllianceGenome:RGD:1309661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human KLHL5 (kelch like family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 219.9), Spleen (RPKM 141.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl5 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43497915..43565833, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43144254..43206192, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44805213..44867075, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 12 Neighboring gene solute carrier family 25, member 51 like 1 Neighboring gene uncharacterized LOC102556650 Neighboring gene transmembrane protein 156 Neighboring gene family with sequence similarity 114, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 5
    Names
    kelch-like 5
    myocardial ischemic preconditioning associated protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047093.1 → NP_001040558.1  kelch-like protein 5

      See identical proteins and their annotated locations for NP_001040558.1

      Status: PROVISIONAL

      Source sequence(s)
      AY641809
      UniProtKB/TrEMBL
      A0A8I6AAB1, Q1EG90
      Related
      ENSRNOP00000004003.4, ENSRNOT00000004003.9
      Conserved Domains (6) summary
      smart00612
      Location:562 → 608
      Kelch; Kelch domain
      PHA03098
      Location:173 → 695
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:457 → 500
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:163 → 266
      BTB; BTB/POZ domain
      pfam01344
      Location:456 → 501
      Kelch_1; Kelch motif
      pfam07707
      Location:275 → 374
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43497915..43565833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250959.5 → XP_006251021.1  kelch-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006251021.1

      UniProtKB/TrEMBL
      A0A8I6AAT7
      Conserved Domains (6) summary
      smart00612
      Location:422 → 468
      Kelch; Kelch domain
      PHA03098
      Location:33 → 555
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:317 → 360
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:23 → 126
      BTB; BTB/POZ domain
      pfam01344
      Location:316 → 361
      Kelch_1; Kelch motif
      pfam07707
      Location:135 → 234
      BACK; BTB And C-terminal Kelch

    2. XM_039091924.2 → XP_038947852.1  kelch-like protein 5 isoform X2

      Conserved Domains (3) summary
      PHA03098
      Location:7 → 429
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:191 → 234
      Kelch; KELCH repeat [structural motif]
      cd18511
      Location:3 → 108
      BACK_KLHL5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5)

    3. XM_039091923.2 → XP_038947851.1  kelch-like protein 5 isoform X3

      Conserved Domains (2) summary
      cl38908
      Location:150 → 279
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:269 → 370
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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