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    Nars2 asparaginyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nars2provided by RGD
    Official Full Name
    asparaginyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1305145
    See related
    EnsemblRapid:ENSRNOG00000011476 AllianceGenome:RGD:1305145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305145
    Summary
    Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 93.8), Adrenal (RPKM 82.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nars2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (160711680..160823311)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151300446..151412086)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (161922132..162035817)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene teneurin transmembrane protein 4 Neighboring gene uncharacterized LOC134483756 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485154 Neighboring gene uncharacterized LOC134485155 Neighboring gene uncharacterized LOC108349194 Neighboring gene GRB2-associated binding protein 2 Neighboring gene ubiquitin specific peptidase 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. Simon M, et al. PLoS Genet, 2015 Mar. PMID 25807530, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC125113

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    asparaginyl-tRNA synthetase
    Names
    Nars2, similar to CG6796-PA
    asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
    probable asparagine--tRNA ligase, mitochondrial
    probable asparaginyl-tRNA synthetase, mitochondrial
    NP_001030093.1
    NP_001385667.1
    XP_038961877.1
    XP_038961884.1
    XP_063141059.1
    XP_063141061.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034921.2 → NP_001030093.1  asparaginyl-tRNA synthetase isoform 2

      See identical proteins and their annotated locations for NP_001030093.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LNQ5, Q3SWT9
      Related
      ENSRNOP00000015784.7, ENSRNOT00000015784.8
      Conserved Domains (2) summary
      cd04318
      Location:44 → 120
      EcAsnRS_like_N; EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB ...
      cl00268
      Location:133 → 389
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    2. NM_001398738.1 → NP_001385667.1  asparaginyl-tRNA synthetase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A485, A0A8I6A5J1
      Related
      ENSRNOP00000087263.1, ENSRNOT00000109218.2
      Conserved Domains (1) summary
      PRK03932
      Location:27 → 474
      asnC; asparaginyl-tRNA synthetase; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      160711680..160823311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284991.1 → XP_063141061.1  asparaginyl-tRNA synthetase isoform X4

      UniProtKB/TrEMBL
      A0A8I6A485

    2. XM_063284989.1 → XP_063141059.1  asparaginyl-tRNA synthetase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7D7, A0A8I6A485
      Related
      ENSRNOP00000111699.1, ENSRNOT00000151636.1

    3. XM_039105949.2 → XP_038961877.1  asparaginyl-tRNA synthetase isoform X2

      Conserved Domains (1) summary
      PRK03932
      Location:27 → 305
      asnC; asparaginyl-tRNA synthetase; Validated

    4. XM_039105956.2 → XP_038961884.1  asparaginyl-tRNA synthetase isoform X3

      UniProtKB/TrEMBL
      Q5I0C6
      Conserved Domains (1) summary
      PRK03932
      Location:14 → 257
      asnC; asparaginyl-tRNA synthetase; Validated
    Nucleotide Protein Strain
    Heading Accession and Version

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