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    Pear1 platelet endothelial aggregation receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pear1provided by RGD
    Official Full Name
    platelet endothelial aggregation receptor 1provided by RGD
    Primary source
    RGD:1305653
    See related
    EnsemblRapid:ENSRNOG00000014243 AllianceGenome:RGD:1305653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305653
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Predicted to act upstream of or within recognition of apoptotic cell. Predicted to be located in lamellipodium and phagocytic cup. Predicted to be active in plasma membrane. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 86.0), Kidney (RPKM 66.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pear1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175504184..175531969, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173206298..173234106, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187114219..187134209, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546356 Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene leucine rich repeat containing 71 Neighboring gene uncharacterized LOC134485635 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor-related receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Absence of Pear1 does not affect murine platelet function in vivo. Criel M, et al. Thromb Res, 2016 Oct. PMID 27614188
    2. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Wu HH, et al. Nat Neurosci, 2009 Dec. PMID 19915564, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188434

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within recognition of apoptotic cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet endothelial aggregation receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134959.1 → NP_001128431.1  platelet endothelial aggregation receptor 1 precursor

      See identical proteins and their annotated locations for NP_001128431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168665
      UniProtKB/TrEMBL
      A0A8I5Y1X3, B5DEG9
      Related
      ENSRNOP00000019502.5, ENSRNOT00000019502.9
      Conserved Domains (3) summary
      pfam00053
      Location:620 → 665
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:25 → 93
      EMI; EMI domain
      cl21504
      Location:535 → 580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175504184..175531969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281628.1 → XP_063137698.1  platelet endothelial aggregation receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1X3

    2. XM_039102054.2 → XP_038957982.1  platelet endothelial aggregation receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1X3, E9PTZ1
      Conserved Domains (3) summary
      pfam00053
      Location:620 → 665
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:25 → 93
      EMI; EMI domain
      cl21504
      Location:535 → 580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. XM_039102056.2 → XP_038957984.1  platelet endothelial aggregation receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1X3, E9PTZ1
      Conserved Domains (3) summary
      pfam00053
      Location:620 → 665
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:25 → 93
      EMI; EMI domain
      cl21504
      Location:535 → 580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    4. XM_063281627.1 → XP_063137697.1  platelet endothelial aggregation receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1X3

    5. XM_063281629.1 → XP_063137699.1  platelet endothelial aggregation receptor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y1X3
    Nucleotide Protein Strain
    Heading Accession and Version

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