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    Smim22 small integral membrane protein 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smim22provided by RGD
    Official Full Name
    small integral membrane protein 22provided by RGD
    Primary source
    RGD:1563547
    See related
    EnsemblRapid:ENSRNOG00000080339 AllianceGenome:RGD:1563547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563547
    Summary
    Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Orthologous to human SMIM22 (small integral membrane protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 44.5), Lung (RPKM 18.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smim22 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11079019..11080804, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10572146..10574339, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10766208..10768044, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glyoxylate reductase 1 homolog Neighboring gene rogdi atypical leucine zipper Neighboring gene septin 12 Neighboring gene dynein axonemal assembly factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation. Polycarpou-Schwarz M, et al. Oncogene, 2018 Aug. PMID 29765154
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108266.1 → NP_001101736.1  small integral membrane protein 22

      See identical proteins and their annotated locations for NP_001101736.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474017
      UniProtKB/TrEMBL
      A6K4P7
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 47
      DUF4713; Domain of unknown function (DUF4713)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11079019..11080804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245805.5 → XP_006245867.1  small integral membrane protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006245867.1

      UniProtKB/TrEMBL
      A6K4P7
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 47
      DUF4713; Domain of unknown function (DUF4713)

    2. XM_063269291.1 → XP_063125361.1  small integral membrane protein 22 isoform X2

    3. XM_006245806.5 → XP_006245868.1  small integral membrane protein 22 isoform X2

      Related
      ENSRNOP00000111262.1, ENSRNOT00000122592.1
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 47
      DUF4713; Domain of unknown function (DUF4713)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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