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    Taf11 TATA-box binding protein associated factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 68776, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Taf11provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 11provided by MGI
    Primary source
    MGI:MGI:1916026
    See related
    Ensembl:ENSMUSG00000024218 AllianceGenome:MGI:1916026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAF2I; PRO214; TAFII28; 1110038O14Rik
    Summary
    Enables DNA binding activity. Predicted to be involved in positive regulation by host of viral transcription; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Located in nucleus. Is expressed in brain; genitourinary system; heart; and tail. Orthologous to human TAF11 (TATA-box binding protein associated factor 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.5), testis adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf11 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28120096..28128723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27901122..27909343, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene ankyrin repeat and SAM domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene t-complex protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, et al. Mol Cell, 2003 Oct. PMID 14580349
    2. Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Langer D, et al. Nat Commun, 2016 Mar 30. PMID 27026076, Free PMC Article
    3. Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. El-Saafin F, et al. Cell Death Differ, 2022 May. PMID 35361962, Free PMC Article
    4. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
    5. Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Tatarakis A, et al. Mol Cell, 2008 Aug 22. PMID 18722179

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear vitamin D receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear vitamin D receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 11
    Names
    TAF(II)28
    TAFII-28
    TFIID subunit p30-beta
    transcription initiation factor TFIID 28 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379368.1 → NP_001366297.1  transcription initiation factor TFIID subunit 11

      Status: VALIDATED

      Source sequence(s)
      AC126040
      UniProtKB/Swiss-Prot
      Q3UZH1, Q99JX1, Q9CT98
      Related
      ENSMUSP00000025057.5, ENSMUST00000025057.5
      Conserved Domains (1) summary
      pfam04719
      Location:108 → 192
      TAFII28; hTAFII28-like protein conserved region

    2. NM_026836.3 → NP_081112.1  transcription initiation factor TFIID subunit 11

      See identical proteins and their annotated locations for NP_081112.1

      Status: VALIDATED

      Source sequence(s)
      AC126040, AK050689, AK133851, BQ030498
      Consensus CDS
      CCDS28571.1
      UniProtKB/Swiss-Prot
      Q3UZH1, Q99JX1, Q9CT98
      Related
      ENSMUSP00000110498.2, ENSMUST00000114848.8
      Conserved Domains (1) summary
      pfam04719
      Location:108 → 192
      TAFII28; hTAFII28-like protein conserved region

    RNA

    1. NR_166634.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126040

    2. NR_166635.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126040

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28120096..28128723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246588.4 → XP_011244890.1  transcription initiation factor TFIID subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_011244890.1

      UniProtKB/Swiss-Prot
      Q3UZH1, Q99JX1, Q9CT98
      Conserved Domains (1) summary
      pfam04719
      Location:108 → 192
      TAFII28; hTAFII28-like protein conserved region

    2. XM_006524862.5 → XP_006524925.1  transcription initiation factor TFIID subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_006524925.1

      UniProtKB/Swiss-Prot
      Q3UZH1, Q99JX1, Q9CT98
      Conserved Domains (1) summary
      pfam04719
      Location:108 → 192
      TAFII28; hTAFII28-like protein conserved region

    3. XM_036160772.1 → XP_036016665.1  transcription initiation factor TFIID subunit 11 isoform X2

      Conserved Domains (1) summary
      cl02176
      Location:108 → 136
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    4. XM_036160771.1 → XP_036016664.1  transcription initiation factor TFIID subunit 11 isoform X2

      Conserved Domains (1) summary
      cl02176
      Location:108 → 136
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JX1.1 GenPept UniProtKB/Swiss-Prot:Q99JX1

    Gene LinkOut

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