A2ml1 alpha-2-macroglobulin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: A2ml1provided by RGD
Official Full Name: alpha-2-macroglobulin-like 1provided by RGD
Primary source: RGD:1565709
See related: EnsemblRapid:ENSRNOG00000007247 AllianceGenome:RGD:1565709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565709
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 177.9), Thymus (RPKM 18.4) and 1 other tissue See more
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Genomic context

Location:: 4q42

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (163501210..163543419, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (161815111..161857286, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (161863609..161907897, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2-macroglobulin-like 1; ovostatin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431784.1 → NP_001418713.1 alpha-2-macroglobulin-like 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6A8Q1, D3ZS19
NM_001431785.1 → NP_001418714.1 alpha-2-macroglobulin-like 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

163501210..163543419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108844.2 → XP_038964772.1 ovostatin homolog

Related

ENSRNOP00000009557.8, ENSRNOT00000009557.8

Conserved Domains (7) summary

cd02897
Location:960 → 1255

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:740 → 830

A2M; Alpha-2-macroglobulin family

pfam01835
Location:122 → 204

A2M_N; MG2 domain

pfam07677
Location:1363 → 1449

A2M_recep; A-macroglobulin receptor

pfam07703
Location:448 → 594

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

pfam17789
Location:340 → 434

MG4; Macroglobulin domain MG4

pfam17791
Location:217 → 303

MG3; Macroglobulin domain MG3