Asns asparagine synthetase (glutamine-hydrolyzing) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asnsprovided by RGD
Official Full Name: asparagine synthetase (glutamine-hydrolyzing)provided by RGD
Primary source: RGD:2162
See related: EnsemblRapid:ENSRNOG00000007546 AllianceGenome:RGD:2162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to aldosterone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma and retinal degeneration. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 212.2), Testes (RPKM 153.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (36752061..36769970, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (35784995..35803474, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (33742876..33761106, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables asparagine synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparagine synthase (glutamine-hydrolyzing) activity	IDA Inferred from Direct Assay more info	PubMed
enables asparagine synthase (glutamine-hydrolyzing) activity	ISO Inferred from Sequence Orthology more info
enables asparagine synthase (glutamine-hydrolyzing) activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-asparagine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in asparagine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in asparagine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within asparagine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to follicle-stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: asparagine synthetase [glutamine-hydrolyzing]

Names: glutamine-dependent asparagine synthetase

NP_037211.2

EC 6.3.5.4

XP_006236151.1

EC 6.3.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.