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    Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362377, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Herc3provided by RGD
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by RGD
    Primary source
    RGD:1307803
    See related
    EnsemblRapid:ENSRNOG00000007304 AllianceGenome:RGD:1307803
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 167.1), Muscle (RPKM 121.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Herc3 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (89282374..89372656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87952202..88042492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (89078670..89169150)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486585 Neighboring gene peptidylprolyl isomerase D, pseudogene 16 Neighboring gene uncharacterized LOC120102287 Neighboring gene nucleosome assembly protein 1-like 5 Neighboring gene family with sequence similarity 13, member A Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC3
    Names
    hect domain and RLD 3
    NP_001102101.1
    XP_006236646.1
    XP_006236647.1
    XP_063142349.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108631.1 → NP_001102101.1  probable E3 ubiquitin-protein ligase HERC3

      See identical proteins and their annotated locations for NP_001102101.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474011
      UniProtKB/TrEMBL
      A0A0G2K5Y2, A6K140, D3ZPP6
      Related
      ENSRNOP00000010241.4, ENSRNOT00000010241.7
      Conserved Domains (3) summary
      COG5184
      Location:2 → 331
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:702 → 1048
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:313 → 377
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      89282374..89372656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286279.1 → XP_063142349.1  probable E3 ubiquitin-protein ligase HERC3 isoform X3

    2. XM_006236585.5 → XP_006236647.1  probable E3 ubiquitin-protein ligase HERC3 isoform X2

      UniProtKB/TrEMBL
      A6K142
      Conserved Domains (4) summary
      COG5021
      Location:420 → 886
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      COG5184
      Location:2 → 331
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:313 → 377
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      cl27008
      Location:702 → 886
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_006236584.4 → XP_006236646.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

      See identical proteins and their annotated locations for XP_006236646.1

      UniProtKB/TrEMBL
      A0A0G2K5Y2, A6K140, D3ZPP6
      Conserved Domains (3) summary
      COG5184
      Location:2 → 331
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:702 → 1048
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:313 → 377
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RNA

    1. XR_005503255.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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