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    Hus1 HUS1 checkpoint clamp component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hus1provided by RGD
    Official Full Name
    HUS1 checkpoint clamp componentprovided by RGD
    Primary source
    RGD:1591976
    See related
    EnsemblRapid:ENSRNOG00000005141 AllianceGenome:RGD:1591976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including DNA integrity checkpoint signaling; DNA metabolic process; and cellular response to ionizing radiation. Predicted to act upstream of or within DNA damage checkpoint signaling; protein phosphorylation; and response to UV. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Orthologous to human HUS1 (HUS1 checkpoint clamp component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 86.4), Heart (RPKM 48.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hus1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (87902458..87917221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (83688702..83703466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (89194086..89208825, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481910 Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene similar to human chromosome 7 open reading frame 57 Neighboring gene uridine phosphorylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining. Wang X, et al. Oncogene, 2006 Mar 23. PMID 16278671
    2. Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Levitt PS, et al. Genomics, 2005 Aug. PMID 15919177
    3. Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. Jiang K, et al. J Biol Chem, 2003 Jul 4. PMID 12676962
    4. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Weiss RS, et al. Curr Biol, 2002 Jan 8. PMID 11790307
    5. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. Cai RL, et al. J Biol Chem, 2000 Sep 8. PMID 10846170

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic DNA integrity checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    checkpoint protein HUS1
    Names
    HUS1 checkpoint homolog
    Hus1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109092.2 → NP_001102562.1  checkpoint protein HUS1 isoform 1

      See identical proteins and their annotated locations for NP_001102562.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KJ83, D3ZNA8
      Related
      ENSRNOP00000006852.5, ENSRNOT00000006852.9
      Conserved Domains (1) summary
      pfam04005
      Location:1 → 280
      Hus1; Hus1-like protein

    2. NM_001394782.1 → NP_001381711.1  checkpoint protein HUS1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOP00000111790.1, ENSRNOT00000136972.1
      Conserved Domains (1) summary
      pfam04005
      Location:1 → 259
      Hus1; Hus1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      87902458..87917221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092298.1 → XP_038948226.1  checkpoint protein HUS1 isoform X2

      Conserved Domains (1) summary
      pfam04005
      Location:1 → 240
      Hus1; Hus1-like protein

    2. XM_063273479.1 → XP_063129549.1  checkpoint protein HUS1 isoform X1

    3. XM_039092300.2 → XP_038948228.1  checkpoint protein HUS1 isoform X3

      Conserved Domains (1) summary
      pfam04005
      Location:1 → 180
      Hus1; Hus1-like protein

    4. XM_063273481.1 → XP_063129551.1  checkpoint protein HUS1 isoform X3

    5. XM_063273480.1 → XP_063129550.1  checkpoint protein HUS1 isoform X3

    RNA

    1. XR_005493003.1 RNA Sequence

    2. XR_005493004.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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