Glyr1 glyoxylate reductase 1 homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glyr1provided by RGD
Official Full Name: glyoxylate reductase 1 homologprovided by RGD
Primary source: RGD:1309459
See related: EnsemblRapid:ENSRNOG00000003065 AllianceGenome:RGD:1309459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPAC; N-pac; RGD1309459; 3930401k13rik
Summary: Predicted to enable several functions, including chromatin-protein adaptor activity; methylated histone binding activity; and nucleosome binding activity. Predicted to be involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nucleosome. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 309.8), Adrenal (RPKM 221.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (11038577..11074093)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (10532036..10567639)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (10725830..10759471)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S544E (e-PCR)
- UniSTS:43298

SHGC-61126 (e-PCR)
- UniSTS:3120

AW545332 (e-PCR)
- UniSTS:180848

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin-protein adaptor activity	IEA Inferred from Electronic Annotation more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in transcription elongation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytokine-like nuclear factor N-PAC

Names: cytokine-like nuclear factor n-pac; nuclear protein NP60; putative oxidoreductase GLYR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007800.3 → NP_001007801.1 cytokine-like nuclear factor N-PAC

See identical proteins and their annotated locations for NP_001007801.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5RKH0

UniProtKB/TrEMBL

A0A8I5ZPH2, A6K4P4

Conserved Domains (3) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:267 → 550

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl21454
Location:209 → 301

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

11038577..11074093

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086260.2 → XP_038942188.1 cytokine-like nuclear factor N-PAC isoform X1

UniProtKB/TrEMBL

A0A8I5ZPH2

Related

ENSRNOP00000004159.6, ENSRNOT00000004159.7
XM_039086261.2 → XP_038942189.1 cytokine-like nuclear factor N-PAC isoform X2

UniProtKB/TrEMBL

A0A8I6GIU5

Related

ENSRNOP00000090372.2, ENSRNOT00000095486.2

Conserved Domains (3) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:187 → 470

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl21454
Location:129 → 221

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_039086262.2 → XP_038942190.1 cytokine-like nuclear factor N-PAC isoform X3

UniProtKB/TrEMBL

A0A8I6GIU5

Conserved Domains (2) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:187 → 464

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
XM_039086263.2 → XP_038942191.1 cytokine-like nuclear factor N-PAC isoform X4

Conserved Domains (2) summary

COG2084
Location:77 → 360

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl21454
Location:19 → 111

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins