Tfpt TCF3 (E2A) fusion partner [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfptprovided by MGI
Official Full Name: TCF3 (E2A) fusion partnerprovided by MGI
Primary source: MGI:MGI:1916964
See related: Ensembl:ENSMUSG00000006335 AllianceGenome:MGI:1916964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FB1; Amida; 2400004F01Rik
Summary: Predicted to enable DNA binding activity and protein kinase binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Ino80 complex. Predicted to colocalize with actin filament. Orthologous to human TFPT (TCF3 fusion partner). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.3), CNS E14 (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.09 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3623323..3632911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3620324..3629929, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent.
Title: Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI450389 (e-PCR)
- UniSTS:179513

RH130105 (e-PCR)
- UniSTS:213393

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ino80 complex	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TCF3 fusion partner homolog

Names: protein amida

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290381.2 → NP_001277310.1 TCF3 fusion partner homolog isoform 1

See identical proteins and their annotated locations for NP_001277310.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC171680

Consensus CDS

CCDS71873.1

UniProtKB/Swiss-Prot

Q3U1J1, Q9EP77

UniProtKB/TrEMBL

Q9CRJ8

Related

ENSMUSP00000104281.4, ENSMUST00000108641.10
NM_023524.3 → NP_076013.1 TCF3 fusion partner homolog isoform 2

See identical proteins and their annotated locations for NP_076013.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC171680

Consensus CDS

CCDS20720.1

UniProtKB/TrEMBL

Q9CRJ8

Related

ENSMUSP00000123636.2, ENSMUST00000155592.8