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    Snx4 sorting nexin 4 [ Mus musculus (house mouse) ]

    Gene ID: 69150, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snx4provided by MGI
    Official Full Name
    sorting nexin 4provided by MGI
    Primary source
    MGI:MGI:1916400
    See related
    Ensembl:ENSMUSG00000022808 AllianceGenome:MGI:1916400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810036H14Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of autophagosome assembly; and positive regulation of histamine secretion by mast cell. Is active in presynaptic endosome. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.3), limb E14.5 (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx4 in Genome Data Viewer
    Location:
    16 B3; 16 23.77 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33071826..33119932)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33251456..33299562)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:33185069-33185370 Neighboring gene oxysterol binding protein-like 11 Neighboring gene STARR-seq mESC enhancer starr_40685 Neighboring gene predicted gene, 52274 Neighboring gene STARR-positive B cell enhancer ABC_E8629 Neighboring gene STARR-seq mESC enhancer starr_40689 Neighboring gene STARR-seq mESC enhancer starr_40691 Neighboring gene STARR-seq mESC enhancer starr_40692 Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene zinc finger protein 148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The endosomal protein sorting nexin 4 is a synaptic protein. Vazquez-Sanchez S, et al. Sci Rep, 2020 Oct 26. PMID 33106523, Free PMC Article
    2. Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1. Kim NY, et al. Alzheimers Res Ther, 2017 Jan 21. PMID 28109317, Free PMC Article
    3. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. Leprince C, et al. J Cell Sci, 2003 May 15. PMID 12668730
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The endosomal protein sorting nexin 4 is a synaptic protein.
      Title: The endosomal protein sorting nexin 4 is a synaptic protein.
    2. Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.
      Title: Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.
    3. Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking
      Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leptin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of histamine secretion by mast cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic endosome IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in presynaptic endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080557.2 → NP_542124.1  sorting nexin-4

      See identical proteins and their annotated locations for NP_542124.1

      Status: PROVISIONAL

      Source sequence(s)
      AC145198
      Consensus CDS
      CCDS28129.1
      UniProtKB/Swiss-Prot
      Q91YJ2
      UniProtKB/TrEMBL
      Q80X54
      Related
      ENSMUSP00000023502.5, ENSMUST00000023502.6
      Conserved Domains (3) summary
      cd06864
      Location:58 → 184
      PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
      cd07622
      Location:205 → 448
      BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
      pfam11221
      Location:324 → 398
      Med21; Subunit 21 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33071826..33119932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YJ2.1 GenPept UniProtKB/Swiss-Prot:Q91YJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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