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    Ap3m1 adaptor-related protein complex 3, mu 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 55946, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ap3m1provided by MGI
    Official Full Name
    adaptor-related protein complex 3, mu 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1929212
    See related
    Ensembl:ENSMUSG00000021824 AllianceGenome:MGI:1929212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200013D09Rik
    Summary
    Predicted to enable small GTPase binding activity. Involved in anterograde synaptic vesicle transport and postsynaptic neurotransmitter receptor internalization. Is active in postsynaptic recycling endosome. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap3m1 in Genome Data Viewer
    Location:
    14 A3; 14 11.58 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21083810..21102603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21033106..21052553, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene predicted gene, 52168 Neighboring gene STARR-seq mESC enhancer starr_36125 Neighboring gene uncharacterized protein C3orf14 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_36127 Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene predicted gene, 30363

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. Mardones GA, et al. J Biol Chem, 2013 Mar 29. PMID 23404500, Free PMC Article
    2. Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1. Nie Z, et al. Dev Cell, 2003 Sep. PMID 12967569
    3. Characterization of the adaptor-related protein complex, AP-3. Simpson F, et al. J Cell Biol, 1997 May 19. PMID 9151686, Free PMC Article
    4. Association of the AP-3 adaptor complex with clathrin. Dell'Angelica EC, et al. Science, 1998 Apr 17. PMID 9545220
    5. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Steinmetz CC, et al. Cell Rep, 2016 Sep 6. PMID 27568566, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that excess mu3A acts independently of the AP-3A complex to reroute AMPAR to recycling endosomes.
      Title: Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
    2. Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex
      Title: Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin-coated vesicle cargo loading, AP-3-mediated NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in melanosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet dense granule organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-3 complex subunit mu-1
    Names
    AP-3 adapter complex mu3A subunit
    AP-3 adaptor complex mu3A subunit
    adapter-related protein complex 3 mu-1 subunit
    adapter-related protein complex 3 subunit mu-1
    adaptor-related protein complex 3 subunit mu-1
    adaptor-related protein complex AP-3, mu 1 subunit
    clathrin adaptor protein mu3A
    mu-adaptin 3A
    mu3A-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018829.4 → NP_061299.3  AP-3 complex subunit mu-1

      See identical proteins and their annotated locations for NP_061299.3

      Status: VALIDATED

      Source sequence(s)
      AC163681, BC090983, BY774570, CD551381
      Consensus CDS
      CCDS26861.1
      UniProtKB/Swiss-Prot
      Q5BKQ6, Q9JKC8
      UniProtKB/TrEMBL
      Q9DBU8
      Related
      ENSMUSP00000117346.2, ENSMUST00000154460.8
      Conserved Domains (2) summary
      cd09260
      Location:165 → 418
      AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21083810..21102603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519292.3 → XP_006519355.1  AP-3 complex subunit mu-1 isoform X1

      See identical proteins and their annotated locations for XP_006519355.1

      UniProtKB/Swiss-Prot
      Q5BKQ6, Q9JKC8
      UniProtKB/TrEMBL
      Q9DBU8
      Conserved Domains (2) summary
      cd09260
      Location:165 → 418
      AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

    2. XM_006519293.3 → XP_006519356.1  AP-3 complex subunit mu-1 isoform X1

      See identical proteins and their annotated locations for XP_006519356.1

      UniProtKB/Swiss-Prot
      Q5BKQ6, Q9JKC8
      UniProtKB/TrEMBL
      Q9DBU8
      Related
      ENSMUSP00000022371.4, ENSMUST00000022371.10
      Conserved Domains (2) summary
      cd09260
      Location:165 → 418
      AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

    RNA

    1. XR_003950866.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKC8.1 GenPept UniProtKB/Swiss-Prot:Q9JKC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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