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    Rtn4ip1 reticulon 4 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 170728, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rtn4ip1provided by MGI
    Official Full Name
    reticulon 4 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2178759
    See related
    Ensembl:ENSMUSG00000019864 AllianceGenome:MGI:2178759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIMP; D10Ertd690e
    Summary
    Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in regulation of dendrite development. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 16.9), kidney adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rtn4ip1 in Genome Data Viewer
    Location:
    10 B2; 10 23.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43777772..43823860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43901807..43947863)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933404K13 gene Neighboring gene STARR-positive B cell enhancer ABC_E1120 Neighboring gene STARR-seq mESC enhancer starr_26522 Neighboring gene STARR-seq mESC enhancer starr_26525 Neighboring gene STARR-seq mESC enhancer starr_26526 Neighboring gene STARR-seq mESC enhancer starr_26527 Neighboring gene glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E6838 Neighboring gene STARR-seq mESC enhancer starr_26529 Neighboring gene STARR-seq mESC enhancer starr_26530 Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene predicted gene, 40636 Neighboring gene STARR-seq mESC enhancer starr_26531 Neighboring gene STARR-seq mESC enhancer starr_26532 Neighboring gene STARR-seq mESC enhancer starr_26533 Neighboring gene preferentially expressed antigen in melanoma like 7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis. Park I, et al. Nat Chem Biol, 2024 Feb. PMID 37884807, Free PMC Article
    2. Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. Angebault C, et al. Am J Hum Genet, 2015 Nov 5. PMID 26593267, Free PMC Article
    3. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). Hu WH, et al. J Neurochem, 2002 Apr. PMID 12067236
    4. Heat shock protein 60 regulates yolk sac erythropoiesis in mice. Duan Y, et al. Cell Death Dis, 2019 Oct 10. PMID 31601784, Free PMC Article
    5. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis.
      Title: Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADPH dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reticulon-4-interacting protein 1, mitochondrial
    Names
    NOGO-interacting mitochondrial protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130892.5 → NP_570962.2  reticulon-4-interacting protein 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_570962.2

      Status: VALIDATED

      Source sequence(s)
      AC153536, AC158637, AK050324
      Consensus CDS
      CCDS23823.1
      UniProtKB/Swiss-Prot
      Q8R1T0, Q924D0
      UniProtKB/TrEMBL
      A0A0R4J0S3
      Related
      ENSMUSP00000060940.6, ENSMUST00000054418.12
      Conserved Domains (2) summary
      cd08248
      Location:43 → 394
      RTN4I1; Human Reticulon 4 Interacting Protein 1
      COG0604
      Location:43 → 395
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RNA

    1. NR_152603.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153536, AC158637, AK050324, CF165433

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      43777772..43823860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155653.1 → XP_036011546.1  reticulon-4-interacting protein 1, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q8R1T0, Q924D0
      Conserved Domains (1) summary
      cd08248
      Location:43 → 363
      RTN4I1; Human Reticulon 4 Interacting Protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924D0.2 GenPept UniProtKB/Swiss-Prot:Q924D0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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