Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf8provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 8provided by MGI
Primary source: MGI:MGI:88328
See related: Ensembl:ENSMUSG00000028362 AllianceGenome:MGI:88328
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD153; Cd30l; CD30LG; Tnlg3a
Summary: Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space and membrane. Is expressed in renal vasculature. Orthologous to human TNFSF8 (TNF superfamily member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 C1; 4 34.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63749439..63779745, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63831202..63861508, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells.
Title: cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells.
CD30L is involved in the regulation of the inflammatory response through inducing homing and differentiation of monocytes via CCL2/CCR2 axis and NF-kappaB pathway in mice with colitis.
Title: CD30L is involved in the regulation of the inflammatory response through inducing homing and differentiation of monocytes via CCL2/CCR2 axis and NF-κB pathway in mice with colitis.
CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
Title: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
Title: CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
this study shows that CD30 ligand deficiency accelerates glioma progression by promoting the formation of tumor immune microenvironment
Title: CD30 ligand deficiency accelerates glioma progression by promoting the formation of tumor immune microenvironment.
CD153 is selectively expressed by Mycobacterium tuberculosis infection (Mtb)-specific effector CD4 T cells in the lung parenchyma and is required for host resistance to Mtb infection. CD4 T-cell expression of CD153 mediates interferon-gamma-independent host resistance to Mtb infection.
Title: Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.
Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).
Title: CD30 ligand is a new therapeutic target for central nervous system autoimmunity.
Altered expression of CD30L and IL-3 may be potential biomarkers for hepatotoxicity induced by D. bulbifera.
Title: Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.
role in the maintenance and activation of IL-17A-producing gammadelta T cells
Title: CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice.
Interference of the CD30-CD30L pathway reduces atherosclerosis development.
Title: Interference of the CD30-CD30L pathway reduces atherosclerosis development.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Markers

L09754 (e-PCR)
- UniSTS:159250

Tnfsf8 (e-PCR), detects polymorphism
- UniSTS:144661

NoName (e-PCR)
- UniSTS:491285

D5Lev21 (e-PCR)
- UniSTS:239714

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CD8-positive, alpha-beta T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 8

Names: CD30 ligand; CD30-L; tumor necrosis factor ligand 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009403.3 → NP_033429.1 tumor necrosis factor ligand superfamily member 8

See identical proteins and their annotated locations for NP_033429.1

Status: PROVISIONAL

Source sequence(s)

AK030916

Consensus CDS

CCDS18264.1

UniProtKB/Swiss-Prot

P32972

UniProtKB/TrEMBL

Q3U033, Q544U1

Related

ENSMUSP00000030047.3, ENSMUST00000030047.3

Conserved Domains (1) summary

pfam00229
Location:118 → 235

TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

63749439..63779745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320114.2 → XP_017175603.1 tumor necrosis factor ligand superfamily member 8 isoform X1

UniProtKB/TrEMBL

Q3U033

Conserved Domains (1) summary

pfam00229
Location:95 → 211

TNF; TNF(tumor Necrosis Factor) family
XM_036163967.1 → XP_036019860.1 tumor necrosis factor ligand superfamily member 8 isoform X2

UniProtKB/TrEMBL

Q3U033

Conserved Domains (1) summary

cl00147
Location:118 → 187

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...